{"id":"W4200262743","doi":"10.3390/microorganisms10010036","title":"Novel Transcriptional and Translational Biomarkers of Tularemia Vaccine Efficacy in a Mouse Inhalation Model: Proof of Concept","year":2021,"lang":"en","type":"article","venue":"Microorganisms","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Defense Threat Reduction Agency","keywords":"Tularemia; Proof of concept; Inhalation; Medicine; Translational research; Computational biology; Immunology; Biology; Virology; Pathology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006983671,0.0005902601,0.0004669337,0.0003581402,0.0001668676,0.0004344851,0.0002548062,0.0006772036,0.00109308],"category_scores_gemma":[0.0002490351,0.0001865588,0.0003254861,0.0001729529,0.0003968861,0.0004224946,0.0002308316,0.001460089,0.0002341791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002848499,"about_ca_system_score_gemma":0.0002862975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000233586,"about_ca_topic_score_gemma":0.0003834367,"domain_scores_codex":[0.9997392,0.00004373171,0.00001623586,0.00006711086,0.00007967559,0.00005396665],"domain_scores_gemma":[0.9997448,0.00004336044,0.00008545953,0.00001975584,0.00005421994,0.00005239094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002238489,0.0001562536,0.0002480637,0.00007954912,0.000006915306,0.00001667159,0.00001567975,0.00009030315,0.9974681,0.00008748192,0.00008264679,0.001524466],"study_design_scores_gemma":[0.00005559224,0.003023669,0.003650184,0.00002158644,0.0000570183,0.0001283488,0.00005197505,0.001784818,0.9887121,0.0001641145,0.002333599,0.00001691274],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9609106,0.003354596,0.03037789,0.0006596249,0.0001750578,0.0003857373,0.002364108,0.0003614817,0.00141088],"genre_scores_gemma":[0.960233,0.003297906,0.02925205,0.0004853878,0.00008473596,0.0006787464,0.002558758,0.00008768604,0.003321812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00109308,"threshold_uncertainty_score":0.003693402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01422364366902616,"score_gpt":0.2473036060719684,"score_spread":0.2330799624029423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}