{"id":"W4200262743","doi":"10.3390/microorganisms10010036","title":"Novel Transcriptional and Translational Biomarkers of Tularemia Vaccine Efficacy in a Mouse Inhalation Model: Proof of Concept","year":2021,"lang":"en","type":"article","venue":"Microorganisms","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"Defense Threat Reduction Agency","keywords":"Tularemia; Proof of concept; Inhalation; Medicine; Translational research; Computational biology; Immunology; Biology; Virology; Pathology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001161408,0.00008348418,0.0001433887,0.00004275847,0.00001770658,0.000005959201,0.00005985584,0.0001162995,0.00004989227],"category_scores_gemma":[0.00002778649,0.00008657726,0.00004546151,0.0001115216,0.00006008738,0.000004925829,0.00002314497,0.00005145621,1.208694e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005641722,"about_ca_system_score_gemma":0.0001502344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001381114,"about_ca_topic_score_gemma":0.00005057904,"domain_scores_codex":[0.9992986,0.00002591564,0.0002472764,0.0002028423,0.0001116251,0.0001137616],"domain_scores_gemma":[0.9996522,0.00001006093,0.00004634509,0.0001111725,0.0001439359,0.00003626727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001754926,0.000192805,0.0005698527,0.00003742789,0.00003357884,6.659023e-7,0.0002041286,0.0006312642,0.9965681,0.0001531427,0.00001666943,0.001416907],"study_design_scores_gemma":[0.0020166,0.00006538858,0.007022638,0.00001423532,0.000007401935,0.000009537906,0.00002231223,0.0009469665,0.9896271,0.00005288724,0.0001335298,0.00008142665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.967469,0.0007327184,0.03125186,0.0001407922,0.00001919893,0.0001374673,0.0001952855,0.00000185726,0.00005183509],"genre_scores_gemma":[0.9959771,0.00003932929,0.003514546,0.0000197157,0.00002082363,0.000002890965,0.0003200768,0.00001275764,0.00009277503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02850809,"threshold_uncertainty_score":0.3530518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01422364366902616,"score_gpt":0.2473036060719684,"score_spread":0.2330799624029423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}