{"id":"W4200266275","doi":"10.1002/hep.32279","title":"Novel low‐avidity glypican‐3 specific CARTs resist exhaustion and mediate durable antitumor effects against HCC","year":2021,"lang":"en","type":"article","venue":"Hepatology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Genentech; National Cancer Institute; Eisai; Bristol-Myers Squibb","keywords":"Avidity; Cancer research; Monoclonal antibody; Epitope; Antigen; In vivo; Immunology; In vitro; Biology; Antibody; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006186326,0.0003146428,0.0001590479,0.0001068056,0.00008556727,0.0001632666,0.0001740458,0.0002165798,0.0007556094],"category_scores_gemma":[0.00007773118,0.00007534665,0.0001400855,0.0000601289,0.00008905069,0.0001179316,0.00009261293,0.0004679022,0.0002052087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002498964,"about_ca_system_score_gemma":0.0001166381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003911563,"about_ca_topic_score_gemma":0.0005383673,"domain_scores_codex":[0.9999298,0.00001208321,0.000004481429,0.0000107001,0.00001461328,0.00002822917],"domain_scores_gemma":[0.9999491,0.000009851012,0.00001130902,0.000006098657,0.000007476679,0.00001611423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001103699,0.00007575088,0.0002063728,0.00002358465,0.000005939013,0.00003428089,0.000009391405,0.0002216817,0.9960496,0.00007927064,0.0001119517,0.003071826],"study_design_scores_gemma":[0.0001292451,0.002325893,0.006779692,0.000007786,0.00005180155,0.0005446578,0.00002436024,0.003568303,0.9814352,0.00006574525,0.005058365,0.000008941741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997839,0.000425885,0.0009173942,0.00003257682,0.000009454175,0.00002027234,0.00007532398,0.00004192727,0.0006382305],"genre_scores_gemma":[0.9970386,0.0002065143,0.001254671,0.00005781206,0.000008926401,0.00002725928,0.0002307556,0.000008191483,0.001167242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007556094,"threshold_uncertainty_score":0.002527773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02622897204125321,"score_gpt":0.2889072019440803,"score_spread":0.2626782299028271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}