{"id":"W4200266275","doi":"10.1002/hep.32279","title":"Novel low‐avidity glypican‐3 specific CARTs resist exhaustion and mediate durable antitumor effects against HCC","year":2021,"lang":"en","type":"article","venue":"Hepatology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Genentech; National Cancer Institute; Eisai; Bristol-Myers Squibb","keywords":"Avidity; Cancer research; Monoclonal antibody; Epitope; Antigen; In vivo; Immunology; In vitro; Biology; Antibody; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003100159,0.0001992687,0.0005922687,0.0001428906,0.0001361338,0.00003150253,0.00008185067,0.0002030567,0.0007948419],"category_scores_gemma":[0.0003076738,0.0001926486,0.00008916231,0.0003213026,0.0002828353,0.00006337647,0.0001133765,0.0004047645,0.0001055251],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000144463,"about_ca_system_score_gemma":0.0003181392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001071066,"about_ca_topic_score_gemma":0.0003182348,"domain_scores_codex":[0.998139,0.0001692454,0.0002832753,0.0005619833,0.0003249701,0.0005215623],"domain_scores_gemma":[0.9986252,0.0003094268,0.00006727484,0.0005237902,0.0001995372,0.0002747981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005040413,0.0002699525,0.0907587,0.000484455,0.000075194,0.003148657,0.0001184216,9.532889e-7,0.8936602,0.0004606861,0.004692171,0.005826542],"study_design_scores_gemma":[0.009834019,0.0005881516,0.2430452,0.0004059956,0.0001463248,0.003340217,0.0001547715,0.001082759,0.609668,0.0002984737,0.1308479,0.0005881978],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902384,0.00207781,0.0001072856,0.002285371,0.0006156057,0.0004098571,0.00001444704,0.00007560184,0.004175607],"genre_scores_gemma":[0.991968,0.002754538,0.0005665915,0.0006481389,0.0003361789,0.00003814908,0.000111119,0.00004005948,0.003537182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2839922,"threshold_uncertainty_score":0.8702962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02622897204125321,"score_gpt":0.2889072019440803,"score_spread":0.2626782299028271,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}