{"id":"W4200268748","doi":"10.3390/biom11121823","title":"Mechanism of Zn2+ and Ca2+ Binding to Human S100A1","year":2021,"lang":"en","type":"article","venue":"Biomolecules","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Russian Science Foundation","keywords":"Biophysics; Chemistry; Calcium; Motility; Conformational isomerism; Zinc; Binding site; Plasma protein binding; Receptor; Crystallography; Biochemistry; Cell biology; Biology; Molecule","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002741037,0.0006088333,0.0004953411,0.00031465,0.000369667,0.0003851536,0.001265473,0.0007407297,0.00264307],"category_scores_gemma":[0.0003998766,0.0003312512,0.0004023658,0.000189514,0.000356519,0.0002411502,0.0004730566,0.000556481,0.001082096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009015275,"about_ca_system_score_gemma":0.0003044356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00456216,"about_ca_topic_score_gemma":0.00214387,"domain_scores_codex":[0.999585,0.00005268075,0.00001428982,0.0001527588,0.0001011132,0.00009407368],"domain_scores_gemma":[0.99986,0.00004022276,0.00002838699,0.00001500036,0.000024655,0.0000316833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003361689,0.00007056617,0.001625156,0.000211494,0.00004498319,0.0003053645,0.00009061758,0.001331181,0.9890431,0.0008087077,0.0005056038,0.005626944],"study_design_scores_gemma":[0.00006302448,0.0001488324,0.006307324,0.00002015494,0.00002480502,0.0005762489,0.00006853414,0.0179952,0.9677685,0.0004671967,0.00652931,0.00003088566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.96334,0.006184998,0.02367251,0.0006595065,0.0000669609,0.0001619889,0.0006010041,0.0004225244,0.004890427],"genre_scores_gemma":[0.9892728,0.0007292214,0.005372284,0.0001819179,0.000008338327,0.00005668965,0.0005099563,0.00004170954,0.00382713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00456216,"threshold_uncertainty_score":0.009071231,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01332192772000544,"score_gpt":0.2656996484498358,"score_spread":0.2523777207298304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}