{"id":"W4200269851","doi":"10.1016/j.bbadis.2021.166335","title":"Deletion of kif3a in CK19 positive cells leads to primary cilia loss, biliary cell proliferation and cystic liver lesions in TAA-treated mice","year":2021,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"National Health and Medical Research Council; Medical Research Council","keywords":"Cilium; Progenitor cell; Pathology; Primary biliary cirrhosis; Biology; Wnt signaling pathway; Hepatocyte; Organoid; Stem cell; Cancer research; Medicine; Cell biology; Immunology; In vitro; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002662788,0.0007600391,0.0006457763,0.002041468,0.0006374852,0.0006545666,0.0007801824,0.001260301,0.006659556],"category_scores_gemma":[0.0003813706,0.0006124311,0.0009496264,0.0006393258,0.0009115327,0.0004922785,0.0004403529,0.002232714,0.001534191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000683735,"about_ca_system_score_gemma":0.0005086813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003717111,"about_ca_topic_score_gemma":0.005037048,"domain_scores_codex":[0.9992787,0.00008188279,0.0001028212,0.0001460919,0.0001991327,0.0001913882],"domain_scores_gemma":[0.998702,0.0002278912,0.0004046783,0.0001100814,0.00007982052,0.0004754865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002857161,0.00007018148,0.0002208391,0.00002272946,0.0000147201,0.0002517721,0.00002404217,0.00007091535,0.9982994,0.0001686566,0.00007344988,0.0004975066],"study_design_scores_gemma":[0.00003993764,0.0002210453,0.004044273,0.000009814357,0.0000328671,0.0005659624,0.00006120762,0.0008633177,0.9926417,0.00007892661,0.001429803,0.00001099253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872432,0.00132561,0.004700125,0.0004740421,0.0002059499,0.00008457071,0.002938309,0.0004694478,0.002558751],"genre_scores_gemma":[0.9799441,0.0008477711,0.002622635,0.0001228067,0.00004144503,0.0001320748,0.001438902,0.0002801035,0.01457023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006659556,"threshold_uncertainty_score":0.02227849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004415807885633043,"score_gpt":0.2139685681455925,"score_spread":0.2095527602599594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}