{"id":"W4200270594","doi":"10.1038/s41594-021-00692-5","title":"Evolution of a histone variant involved in compartmental regulation of NAD metabolism","year":2021,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"","keywords":"NAD+ kinase; Chromatin; Biology; Histone; Biochemistry; Cell biology; Poly ADP ribose polymerase; Genetics; Gene; Enzyme; Polymerase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003007098,0.0003251499,0.0003104329,0.0003368186,0.0003749847,0.0006261005,0.0005708791,0.0009594684,0.002310219],"category_scores_gemma":[0.000385532,0.000258155,0.0004239749,0.0004176859,0.0003757324,0.000303444,0.0005530039,0.001063871,0.0008318396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000524175,"about_ca_system_score_gemma":0.0002526043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00142672,"about_ca_topic_score_gemma":0.001434095,"domain_scores_codex":[0.9998541,0.00001934534,0.00001042387,0.00004436017,0.00003503844,0.0000367427],"domain_scores_gemma":[0.9996743,0.00006072705,0.00007542943,0.00006825486,0.00004850455,0.00007282529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002510296,0.00002560216,0.002545795,0.00002060307,0.00003638338,0.0004531757,0.00004157186,0.000368186,0.9902603,0.0008131574,0.0000768282,0.005107283],"study_design_scores_gemma":[0.0001308301,0.000648172,0.1187153,0.00004703318,0.000235096,0.007749008,0.0003503738,0.008953284,0.8420954,0.001646608,0.01931889,0.0001100177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869816,0.0005314075,0.008378987,0.0003615879,0.00009538249,0.0000198875,0.0005450153,0.0001409323,0.002945197],"genre_scores_gemma":[0.9946149,0.0002147651,0.002543312,0.0001955484,0.00002094419,0.000005268279,0.0003545131,0.00008383398,0.001966895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002310219,"threshold_uncertainty_score":0.007728457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007885386370023388,"score_gpt":0.3458031962690122,"score_spread":0.3379178098989888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}