{"id":"W4200280009","doi":"10.1002/1873-3468.14256","title":"Structural basis for the recognition of the S2, S5‐phosphorylated RNA polymerase II CTD by the mRNA anti‐terminator protein hSCAF4","year":2021,"lang":"en","type":"article","venue":"FEBS Letters","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Natural Science Foundation of China; Ontario Genomics Institute; Genome Canada; Canadian Institutes of Health Research; AbbVie","keywords":"CTD; RNA polymerase II; Transcription (linguistics); Terminator (solar); Polyadenylation; Messenger RNA; Molecular biology; Chemistry; Binding site; Transcription factor II F; Transcription factor II E; Cleavage (geology); RNA; Phosphorylation; Cell biology; Biology; RNA polymerase; Biochemistry; Gene; Gene expression; Promoter; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008002372,0.0003592212,0.0002174808,0.0001007203,0.0003128341,0.0002951583,0.0003869387,0.0003753867,0.001431512],"category_scores_gemma":[0.0001204311,0.0001908163,0.0003232503,0.00008603928,0.0003817668,0.0001863732,0.000203332,0.000409669,0.0004536756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004591542,"about_ca_system_score_gemma":0.0002609419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001343992,"about_ca_topic_score_gemma":0.0009748135,"domain_scores_codex":[0.9999312,0.00001107616,0.000004141489,0.00001887784,0.00001740389,0.00001727758],"domain_scores_gemma":[0.9999202,0.00001056956,0.00002087849,0.000005114732,0.000008645392,0.00003445746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003667691,0.0000498596,0.001219197,0.0000616041,0.00001643715,0.0004699288,0.00004802598,0.001565882,0.9934528,0.001385315,0.0001080351,0.001256088],"study_design_scores_gemma":[0.0001900829,0.0004659311,0.02815195,0.00002139634,0.00004247413,0.0009429588,0.0002073451,0.03002958,0.9353215,0.001145087,0.003437847,0.00004390072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961404,0.000402658,0.002128593,0.00007520094,0.00002128942,0.0000154832,0.0000729268,0.00002958377,0.001113847],"genre_scores_gemma":[0.9981539,0.0001116762,0.001029863,0.00004133464,0.00000583722,0.000007173757,0.0001464159,0.000004798573,0.0004989584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001431512,"threshold_uncertainty_score":0.004788935,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026013026905678,"score_gpt":0.2381577467481558,"score_spread":0.227897616479099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}