{"id":"W4200280009","doi":"10.1002/1873-3468.14256","title":"Structural basis for the recognition of the S2, S5‐phosphorylated RNA polymerase II CTD by the mRNA anti‐terminator protein hSCAF4","year":2021,"lang":"en","type":"article","venue":"FEBS Letters","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Natural Science Foundation of China; Ontario Genomics Institute; Genome Canada; Canadian Institutes of Health Research; AbbVie","keywords":"CTD; RNA polymerase II; Transcription (linguistics); Terminator (solar); Polyadenylation; Messenger RNA; Molecular biology; Chemistry; Binding site; Transcription factor II F; Transcription factor II E; Cleavage (geology); RNA; Phosphorylation; Cell biology; Biology; RNA polymerase; Biochemistry; Gene; Gene expression; Promoter; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000183025,0.0001242397,0.0001056956,0.00001203767,0.0004007142,0.0000402435,0.0003233011,0.00007271082,0.00004742257],"category_scores_gemma":[0.0001944708,0.00006489593,0.0001643846,0.0001247117,0.0001498228,0.000005588967,0.0001448662,0.0001401384,0.000001602616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001455852,"about_ca_system_score_gemma":0.00006665377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000125356,"about_ca_topic_score_gemma":0.0000258174,"domain_scores_codex":[0.9990355,0.0001117665,0.0001695757,0.0002289204,0.0001797576,0.0002744319],"domain_scores_gemma":[0.9993054,0.00004557806,0.00009625946,0.0004219103,0.00008826588,0.00004254714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007465796,0.00001205241,0.0001753199,0.00001656001,0.00007351188,0.000002098762,0.00004500173,0.000005702873,0.9796677,0.000003833938,0.01077373,0.009149815],"study_design_scores_gemma":[0.0003931807,0.00006935821,0.001300348,0.00002996316,0.00002483124,0.00001216894,0.000106538,0.0001750397,0.9934126,0.00001322483,0.004363518,0.00009925507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819222,0.0008674195,0.00009001144,0.01629885,0.0001212708,0.0005163797,0.0001472642,0.000005067093,0.0000315427],"genre_scores_gemma":[0.9956385,0.0000385345,0.00006102826,0.002827734,0.0001209561,0.00007617515,0.0000868468,0.00001829692,0.001131851],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01374486,"threshold_uncertainty_score":0.308201,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026013026905678,"score_gpt":0.2381577467481558,"score_spread":0.227897616479099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}