{"id":"W4200282980","doi":"10.2196/preprints.34711","title":"Efficacy and Tolerability of Two Novel “Standard of Care” Treatments—Intranasal Esketamine Versus Intravenous Ketamine—for Treatment-Resistant Depression in Naturalistic Clinical Practice: Protocol for a Pilot Observational Study (Preprint)","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Literature Analysis and Criticism","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Tolerability; Ketamine; Treatment-resistant depression; Medicine; Observational study; Internal medicine; Anesthesia; Adverse effect; Major depressive disorder","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02952651,0.002538347,0.004056636,0.001316147,0.003250644,0.001856251,0.003204097,0.003272547,0.02233375],"category_scores_gemma":[0.03264429,0.001888842,0.005080685,0.001526137,0.0022757,0.002963477,0.00167777,0.00443579,0.004389137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005653662,"about_ca_system_score_gemma":0.01691149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003080384,"about_ca_topic_score_gemma":0.004701745,"domain_scores_codex":[0.9808149,0.01204733,0.003158637,0.001182409,0.001640914,0.001155803],"domain_scores_gemma":[0.9745429,0.006603123,0.00544787,0.002741724,0.007466088,0.003198331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6607661,0.1513196,0.01281538,0.02255763,0.001991315,0.0007304514,0.006019419,0.004551189,0.005281243,0.00328854,0.03443182,0.09624748],"study_design_scores_gemma":[0.5430002,0.3221498,0.05472089,0.005000046,0.001073498,0.0002098534,0.003419178,0.00335765,0.004475579,0.00257617,0.0595279,0.0004891848],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01250983,0.0000610889,0.0006893352,0.0001218241,0.00008511155,0.9849866,0.001045282,0.00002292875,0.0004779999],"genre_scores_gemma":[0.005743264,0.00004392775,0.001654956,0.00009051998,0.00002856188,0.9920349,0.0002748086,0.000002204698,0.0001270128],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02952651,"threshold_uncertainty_score":0.156153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1726447461237972,"score_gpt":0.4907775045703281,"score_spread":0.318132758446531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}