{"id":"W4200282995","doi":"10.1016/j.cbi.2021.109768","title":"Biological Effects of Gyrophoric Acid and Other Lichen Derived Metabolites, on Cell Proliferation, Apoptosis and Cell Signaling pathways","year":2021,"lang":"en","type":"review","venue":"Chemico-Biological Interactions","topic":"Lichen and fungal ecology","field":"Agricultural and Biological Sciences","cited_by":41,"is_retracted":false,"has_abstract":false,"ca_institutions":"NOSM University; Lakehead University","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Mitacs","keywords":"Usnic acid; Apoptosis; Metabolite; Biochemistry; Cell growth; Biology; Cell; Cancer cell; Cell cycle; Biological activity; Programmed cell death; Lichen; Metabolic pathway; Chemistry; Cancer; Enzyme; Botany","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001904739,0.0005423586,0.001597118,0.00004542483,0.0002115821,0.00007908289,0.0002729323,0.0007711091,0.0004611092],"category_scores_gemma":[0.0003825038,0.0002052604,0.0004152511,0.0003653658,0.0002140077,0.00006244769,0.0002624206,0.0006889802,0.00002720398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004900237,"about_ca_system_score_gemma":0.0000252612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001732326,"about_ca_topic_score_gemma":0.00000343476,"domain_scores_codex":[0.9974954,0.0004372648,0.000693926,0.0008680088,0.0001059444,0.0003994681],"domain_scores_gemma":[0.9966947,0.002410836,0.0004557022,0.0001275039,0.0001081539,0.0002030517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002114793,0.0005456512,0.0001763198,0.0009382576,0.0001118924,0.00000528073,0.00007940538,8.862245e-8,0.8933623,0.0002381897,0.0002265562,0.1042949],"study_design_scores_gemma":[0.0002547627,0.0009544166,0.0001422443,0.001090058,0.0003949104,0.00004288562,0.000187193,0.000003197181,0.4456222,0.0001513554,0.5504097,0.0007469775],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.238414,0.7597539,0.000003289315,0.00004319636,0.0002366168,0.0006470644,0.0001551041,0.00006294812,0.0006838211],"genre_scores_gemma":[0.1646224,0.833636,0.00019351,0.0003429725,0.0003981091,0.0002914693,0.0003851403,0.000005976102,0.0001243121],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5501832,"threshold_uncertainty_score":0.8370275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05818623483874659,"score_gpt":0.2716998698386276,"score_spread":0.213513634999881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}