{"id":"W4200283230","doi":"10.3390/diagnostics11122303","title":"Integrated Genomic, Transcriptomic and Proteomic Analysis for Identifying Markers of Alzheimer’s Disease","year":2021,"lang":"en","type":"article","venue":"Diagnostics","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; Innovative Medicines Initiative; Eisai; Northern California Institute for Research and Education; Illinois Department of Public Health; Rush University; Servier; CurePSP; Pfizer; Biogen; BioClinica; Meso Scale Diagnostics; Mayo Foundation for Medical Education and Research; F. Hoffmann-La Roche; Mayo Clinic; University of Southern California; Michael J. Fox Foundation for Parkinson's Research; Emory University; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; Translational Genomics Research Institute; Novartis Pharmaceuticals Corporation; Arizona Department of Health Services; Arizona Biomedical Research Commission; Foundation for the National Institutes of Health","keywords":"Expression quantitative trait loci; Single-nucleotide polymorphism; Genome-wide association study; Candidate gene; Quantitative trait locus; Biology; Computational biology; Genetic association; Disease; Transcriptome; Genotype; Genetics; Gene; Bioinformatics; Gene expression; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001308043,0.0001209317,0.0002037574,0.00005376014,0.00005014919,0.00002943613,0.00008395184,0.00008682549,0.00001288216],"category_scores_gemma":[0.0001273482,0.0001230206,0.0001699455,0.0001261996,0.00006458111,0.000003170515,0.00005302846,0.00005089378,8.140108e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006812016,"about_ca_system_score_gemma":0.0001069753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000852895,"about_ca_topic_score_gemma":0.00003700659,"domain_scores_codex":[0.9992643,0.00002431046,0.0002821842,0.0002077897,0.00005422129,0.0001672055],"domain_scores_gemma":[0.9994103,0.00003622106,0.00009642472,0.0002382572,0.0001163164,0.0001024884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001090927,0.0004151982,0.09241419,0.0006395051,0.008852387,0.00002779833,0.0005285108,0.00401175,0.8544961,0.001470575,0.00986641,0.02618669],"study_design_scores_gemma":[0.00559825,0.0006558077,0.4179655,0.0002322765,0.01347389,0.00002048011,0.001206668,0.06528725,0.4645551,0.003331108,0.02580949,0.001864109],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9335979,0.006742506,0.05865234,0.00009056127,0.0001200444,0.0003456661,0.000383479,0.000005447855,0.00006211417],"genre_scores_gemma":[0.9906436,0.001779287,0.006286662,0.0001604007,0.0000598497,0.00004074273,0.0009498789,0.00001678111,0.00006283854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3899409,"threshold_uncertainty_score":0.5016635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01925217328744081,"score_gpt":0.2566727745186089,"score_spread":0.2374206012311681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}