{"id":"W4200283230","doi":"10.3390/diagnostics11122303","title":"Integrated Genomic, Transcriptomic and Proteomic Analysis for Identifying Markers of Alzheimer’s Disease","year":2021,"lang":"en","type":"article","venue":"Diagnostics","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; National Institute of Neurological Disorders and Stroke; IXICO; H. Lundbeck A/S; Innovative Medicines Initiative; Eisai; Northern California Institute for Research and Education; Illinois Department of Public Health; Rush University; Servier; CurePSP; Pfizer; Biogen; BioClinica; Meso Scale Diagnostics; Mayo Foundation for Medical Education and Research; F. Hoffmann-La Roche; Mayo Clinic; University of Southern California; Michael J. Fox Foundation for Parkinson's Research; Emory University; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Association; Translational Genomics Research Institute; Novartis Pharmaceuticals Corporation; Arizona Department of Health Services; Arizona Biomedical Research Commission; Foundation for the National Institutes of Health","keywords":"Expression quantitative trait loci; Single-nucleotide polymorphism; Genome-wide association study; Candidate gene; Quantitative trait locus; Biology; Computational biology; Genetic association; Disease; Transcriptome; Genotype; Genetics; Gene; Bioinformatics; Gene expression; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00119005,0.0005129786,0.0008417531,0.003111353,0.0002679371,0.0010045,0.0002958259,0.0003184228,0.001592962],"category_scores_gemma":[0.0008901126,0.0002545342,0.0005894678,0.003041874,0.0001877951,0.0004600874,0.0004918784,0.0003671276,0.0006463404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003356706,"about_ca_system_score_gemma":0.0005468618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001007117,"about_ca_topic_score_gemma":0.001819236,"domain_scores_codex":[0.999563,0.0001234212,0.0000310352,0.0001292725,0.000120237,0.00003304152],"domain_scores_gemma":[0.9996736,0.0001225303,0.00006153912,0.00004566584,0.0000616425,0.00003516608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001419516,0.0003532286,0.0695694,0.001275217,0.001021041,0.0005432615,0.0001458444,0.008675074,0.7100629,0.003902562,0.003188205,0.1998438],"study_design_scores_gemma":[0.0002645985,0.001621082,0.4972032,0.0003346112,0.002856835,0.00262595,0.0005951769,0.1906839,0.2116828,0.03947773,0.05244144,0.0002126203],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.610674,0.02627874,0.311844,0.001738683,0.0002448734,0.0004302642,0.0347753,0.002997336,0.01101677],"genre_scores_gemma":[0.6989638,0.007912195,0.2724649,0.0005992456,0.0001750355,0.0003924469,0.01710196,0.000123033,0.002267336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003111353,"threshold_uncertainty_score":0.006293654,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01925217328744081,"score_gpt":0.2566727745186089,"score_spread":0.2374206012311681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}