{"id":"W4200293462","doi":"10.1002/cbic.202100600","title":"Selection of M<sup>2+</sup>‐Independent RNA‐Cleaving DNAzymes with Side‐Chains Mimicking Arginine and Lysine","year":2021,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of British Columbia Hospital","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Deoxyribozyme; Stereochemistry; Ribozyme; Nucleobase; Imidazole; Chemistry; Combinatorial chemistry; Nucleotide; Cleave; Cleavage (geology); Nucleoside; RNA; Nucleic acid; DNA; Guanidine; Oligonucleotide; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001272612,0.00020605,0.0002632395,0.00005495547,0.0000817743,0.00002531121,0.00007528731,0.0001662953,0.000004395396],"category_scores_gemma":[0.00008251717,0.0001821616,0.00008818193,0.0002367385,0.0001157039,0.000006521698,0.0001146569,0.0001168333,4.123366e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002096785,"about_ca_system_score_gemma":0.0000666624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001057689,"about_ca_topic_score_gemma":0.00002552932,"domain_scores_codex":[0.9988577,0.00003006245,0.0002351521,0.0004841216,0.000163665,0.0002292884],"domain_scores_gemma":[0.9992335,0.00001243996,0.0001415807,0.0002881846,0.0002516345,0.00007260626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005805044,0.00006755588,0.001484687,0.00004113447,0.0001316516,0.000008993302,0.00004616646,0.00003953262,0.9951432,0.00003128855,0.0001208343,0.002826859],"study_design_scores_gemma":[0.0004161956,0.0001529777,0.0005325196,0.00007160984,0.00008314185,0.0001186648,0.0003341152,0.0004600708,0.9969211,0.00002839727,0.0006452919,0.0002359041],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967475,0.0006066433,0.001506358,0.0002361076,0.00001151218,0.00007331355,0.00000839687,0.00003963989,0.0007705537],"genre_scores_gemma":[0.9910492,0.0002826686,0.007269854,0.0001205283,0.0001351885,0.000004588007,0.0001233831,0.00002734332,0.0009871955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005763496,"threshold_uncertainty_score":0.7428333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006663726745170597,"score_gpt":0.2361433971249428,"score_spread":0.2294796703797722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}