{"id":"W4200308292","doi":"10.3233/jad-201504","title":"Association of Lipidomics Signatures in Blood with Clinical Progression in Preclinical and Prodromal Alzheimer’s Disease","year":2021,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research","keywords":"Lipidomics; Disease; Metabolomics; Biomarker; Lipid metabolism; Peripheral blood; Association (psychology)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001105609,0.0004233872,0.0003632847,0.001080189,0.0002265579,0.0005744934,0.0001950127,0.0003978293,0.00109941],"category_scores_gemma":[0.002388241,0.0001479356,0.0002705124,0.0006769397,0.0002073567,0.0002619709,0.000368892,0.0005046079,0.0002022445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002113511,"about_ca_system_score_gemma":0.0002524133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001267343,"about_ca_topic_score_gemma":0.001632992,"domain_scores_codex":[0.9997644,0.00007447472,0.00002426551,0.00006531537,0.00004012536,0.00003135483],"domain_scores_gemma":[0.9988538,0.0004092848,0.0003935351,0.00008461782,0.0001350941,0.0001236409],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002311955,0.00009779844,0.974748,0.00003435173,0.000222847,0.0001589531,0.00009424111,0.0007438478,0.01082981,0.0001163914,0.0001261925,0.0105156],"study_design_scores_gemma":[0.00001773261,0.0002113431,0.9914066,0.000009115482,0.00009360166,0.0003904023,0.00008754488,0.004572181,0.002514547,0.0004965023,0.0001913621,0.000009166504],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980388,0.0002821835,0.001004555,0.00004477877,0.000003475914,0.000007850159,0.0002921943,0.00001307338,0.0003131315],"genre_scores_gemma":[0.998521,0.00008768977,0.0008493094,0.00001660058,0.000004916931,0.000007400437,0.000350727,0.000004443865,0.0001578827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001267343,"threshold_uncertainty_score":0.005847096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02478274234594407,"score_gpt":0.3385967244578806,"score_spread":0.3138139821119366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}