{"id":"W4200309579","doi":"10.1136/bmjopen-2021-053156","title":"Targeted Interventions in Tourette’s using Advanced Neuroimaging and Stimulation (TITANS): study protocol for a double-blind, randomised controlled trial of transcranial magnetic stimulation (TMS) to the supplementary motor area in children with Tourette’s syndrome","year":2021,"lang":"en","type":"article","venue":"BMJ Open","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services; University of Calgary","funders":"Canadian Institutes of Health Research; Mathison Centre for Mental Health Research and Education; Alberta Children's Hospital Foundation; Children's Hospital Foundation; National Institute of Mental Health; Assurex Health; Branch Out Neurological Foundation; Alberta Health Services; Pfizer","keywords":"Transcranial magnetic stimulation; Tourette syndrome; Medicine; Tics; Randomized controlled trial; Clinical trial; Physical therapy; Physical medicine and rehabilitation; Psychiatry; Internal medicine; Stimulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008249971,0.005644613,0.008456811,0.001517752,0.002221417,0.001683866,0.002823228,0.004649718,0.0347879],"category_scores_gemma":[0.006602067,0.002360661,0.002640032,0.00128341,0.002968802,0.001545603,0.001186774,0.004580156,0.005385842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002644572,"about_ca_system_score_gemma":0.009012623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002710614,"about_ca_topic_score_gemma":0.005481895,"domain_scores_codex":[0.9930916,0.003053737,0.0006758146,0.001074001,0.0009548623,0.001149844],"domain_scores_gemma":[0.9969115,0.0007168447,0.0007488452,0.0003392591,0.0004262167,0.0008574768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9617726,0.02011804,0.000282465,0.002492024,0.0004363252,0.0000943393,0.000132696,0.0007839535,0.002745166,0.000614044,0.002373713,0.008154684],"study_design_scores_gemma":[0.9633656,0.03199576,0.0006800107,0.0001137626,0.0001463829,0.00001915001,0.0000164956,0.0003518403,0.000345115,0.0002242172,0.002716581,0.00002499031],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.031369,0.0004883286,0.001279945,0.0002644936,0.0005021833,0.9631494,0.001561308,0.0001413083,0.001244164],"genre_scores_gemma":[0.02067786,0.000312022,0.002093333,0.0002915227,0.0001674585,0.9751006,0.0002882879,0.000008863597,0.001060107],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.0347879,"threshold_uncertainty_score":0.1163771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07134829449872605,"score_gpt":0.4280429641714926,"score_spread":0.3566946696727665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}