{"id":"W4200312704","doi":"10.1182/blood-2021-146940","title":"Efficacy of Daratumumab, Lenalidomide, and Dexamethasone in Transplant-Ineligible Patients with Newly Diagnosed Multiple Myeloma and Impaired Renal Function from the Phase 3 Maia Study Based on Lenalidomide Starting Dose","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Alberta; University of Calgary","funders":"","keywords":"Lenalidomide; Medicine; Multiple myeloma; Daratumumab; Dexamethasone; Internal medicine; Carfilzomib; Oncology; Phases of clinical research; Renal function; Bortezomib; Urology; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001875137,0.000698987,0.001873803,0.0002660516,0.0003921005,0.001068243,0.0006787896,0.000676671,0.00226728],"category_scores_gemma":[0.00111704,0.0004375172,0.002176862,0.0003317498,0.0006297127,0.0005735745,0.0005397893,0.002586331,0.000427121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008603725,"about_ca_system_score_gemma":0.001246427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005515839,"about_ca_topic_score_gemma":0.002178267,"domain_scores_codex":[0.9994274,0.0002749449,0.00005106815,0.00009466846,0.00006602819,0.00008585762],"domain_scores_gemma":[0.9990387,0.0001725114,0.0002488712,0.00007801108,0.00003672832,0.0004252784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.884296,0.02133325,0.02550993,0.0005486766,0.002133964,0.0002101125,0.000184884,0.001241399,0.01182572,0.0001564117,0.001773664,0.05078603],"study_design_scores_gemma":[0.5212061,0.4041746,0.06602621,0.0001113172,0.001717375,0.0004172793,0.00007459234,0.0009367163,0.002218871,0.0002444702,0.002826547,0.00004587615],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944991,0.002606901,0.0001518764,0.0003037159,0.0000933734,0.0005882977,0.0007042667,0.00001799537,0.001034337],"genre_scores_gemma":[0.9958658,0.0008888014,0.0003733782,0.0005448145,0.0001119081,0.0005645319,0.001108542,0.000005321004,0.0005368371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00226728,"threshold_uncertainty_score":0.009916782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02043308320442096,"score_gpt":0.2753407263694819,"score_spread":0.254907643165061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}