{"id":"W4200313047","doi":"10.1002/cmdc.202100733","title":"Efficient Synthesis of Benzothiazinone Analogues with Activity against Intracellular <i>Mycobacterium tuberculosis</i>","year":2021,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Antimycobacterial; Quinazolinone; Mycobacterium tuberculosis; Chemistry; Combinatorial chemistry; Thiourea; Broth microdilution; Resazurin; Stereochemistry; In vitro; Tuberculosis; Biochemistry; Minimum inhibitory concentration; Organic chemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001483223,0.0003269712,0.0002525416,0.0001539307,0.0001325023,0.000155639,0.0002925076,0.0002151682,0.002023496],"category_scores_gemma":[0.0001318862,0.000134539,0.0001749052,0.000236062,0.0001180844,0.0001410016,0.000195527,0.0003398596,0.0006761354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002270096,"about_ca_system_score_gemma":0.0003186028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004349517,"about_ca_topic_score_gemma":0.001301565,"domain_scores_codex":[0.9998975,0.00001707464,0.000009523936,0.0000173379,0.00002643361,0.00003213222],"domain_scores_gemma":[0.9999442,0.000006295994,0.00001755022,0.000006517972,0.00001365635,0.00001169313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008933104,0.00004123221,0.00007400501,0.0001595818,0.00000743792,0.0001059416,0.00002902683,0.0003709439,0.9917324,0.0003539958,0.0001815422,0.006854572],"study_design_scores_gemma":[0.00007204439,0.0008525767,0.001314491,0.0000147216,0.00001720586,0.0002258864,0.00001370051,0.0006911079,0.9850177,0.00007732494,0.0116902,0.00001287432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9262141,0.0101075,0.04047511,0.0003292246,0.0001258082,0.0006768462,0.001966963,0.0004872979,0.01961714],"genre_scores_gemma":[0.9747186,0.004221865,0.01526371,0.00007724546,0.00001733668,0.0001700709,0.0007556788,0.00003374507,0.004741671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002023496,"threshold_uncertainty_score":0.00676924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009205164694648238,"score_gpt":0.2097157941187638,"score_spread":0.2005106294241155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}