{"id":"W4200313579","doi":"10.1139/cjpp-2021-0606","title":"Delta-tocotrienol enhances the anti-tumor effects of interferon alpha through reactive oxygen species and Erk/MAPK signaling pathways in hepatocellular carcinoma cells","year":2021,"lang":"en","type":"article","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Antioxidant Activity and Oxidative Stress","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Combination therapy; MAPK/ERK pathway; Cancer research; Tocotrienol; Apoptosis; Reactive oxygen species; Cancer; Pharmacology; Medicine; Hepatocellular carcinoma; Immunology; Signal transduction; Biology; Internal medicine; Antioxidant; Vitamin E; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007889241,0.0002535095,0.0002445164,0.0001990098,0.00009890116,0.0001367146,0.00009103736,0.0001592722,0.001106935],"category_scores_gemma":[0.00006705624,0.00007046556,0.0002141569,0.0001475039,0.00008542222,0.0001523803,0.0001059343,0.0003676731,0.0001529792],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001737563,"about_ca_system_score_gemma":0.0002338338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007145559,"about_ca_topic_score_gemma":0.001338708,"domain_scores_codex":[0.9999524,0.00001023536,0.000005752741,0.000005740137,0.00001269981,0.0000130772],"domain_scores_gemma":[0.9999666,0.000006758176,0.000008960816,0.000003474186,0.000006141909,0.000008026465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007854196,0.0001127822,0.0002832449,0.000102544,0.00001070889,0.00006759749,0.00001675457,0.00008368753,0.9932277,0.00005246294,0.00004595176,0.005211224],"study_design_scores_gemma":[0.00008655772,0.001740483,0.00911577,0.00001181507,0.00005526428,0.0002206033,0.00005431816,0.0008580248,0.9854858,0.00008500668,0.002280353,0.000006020543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920326,0.004780088,0.001252487,0.0001358179,0.00004017848,0.00002755891,0.0001606076,0.00004456298,0.00152599],"genre_scores_gemma":[0.9957708,0.001949319,0.0007224818,0.00005538662,0.000009221319,0.00002422013,0.0001410546,0.000003870134,0.001323515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001106935,"threshold_uncertainty_score":0.003703117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02061845392264056,"score_gpt":0.2544366217244925,"score_spread":0.2338181678018519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}