{"id":"W4200320597","doi":"10.1158/1535-7163.targ-21-p239","title":"Abstract P239: Safety and efficacy of copanlisib in combination with nivolumab: A phase Ib study in patients with advanced solid tumors","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Tolerability; Nivolumab; Internal medicine; Pharmacodynamics; Cancer; Pharmacokinetics; Gastroenterology; Oncology; Adverse effect; Pharmacology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001241084,0.000182961,0.000406997,0.0001213815,0.00002731163,0.00001234358,0.00005813745,0.00005077699,0.00002835913],"category_scores_gemma":[0.000006446507,0.0001498197,0.00003416077,0.0005032505,0.0000931921,0.00006333239,0.00001671149,0.0001773184,1.832862e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001918785,"about_ca_system_score_gemma":0.0002757794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002109941,"about_ca_topic_score_gemma":0.0006497012,"domain_scores_codex":[0.9987298,0.00005920099,0.0003681406,0.0002983374,0.0003385178,0.0002060072],"domain_scores_gemma":[0.9993358,0.00002927461,0.0001532724,0.0002693622,0.0001671933,0.00004506571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.07154647,0.01193215,0.6003209,0.0002221921,0.00084522,0.0004286785,0.003988986,0.000505792,0.07035483,0.00001711669,0.00000167541,0.239836],"study_design_scores_gemma":[0.07673793,0.003669402,0.9012908,0.0005081207,0.000114049,0.000004221363,0.000560608,0.00008074813,0.01668805,0.000005377483,0.0001496418,0.0001909889],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968781,0.001725711,0.00009773835,0.0001711237,0.00003184873,0.0009900111,0.00001676133,0.00001206798,0.00007666133],"genre_scores_gemma":[0.9991128,0.0002522533,0.0001394696,0.0003721991,0.000005086131,0.00003305058,0.00003564478,0.0000343771,0.00001515978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3009699,"threshold_uncertainty_score":0.6109468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01232018435498204,"score_gpt":0.3024308497985526,"score_spread":0.2901106654435706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}