{"id":"W4200320597","doi":"10.1158/1535-7163.targ-21-p239","title":"Abstract P239: Safety and efficacy of copanlisib in combination with nivolumab: A phase Ib study in patients with advanced solid tumors","year":2021,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Tolerability; Nivolumab; Internal medicine; Pharmacodynamics; Cancer; Pharmacokinetics; Gastroenterology; Oncology; Adverse effect; Pharmacology; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004906001,0.0008119282,0.001330486,0.000204471,0.0004061928,0.0007446475,0.0004319787,0.0004978793,0.002467735],"category_scores_gemma":[0.0003684725,0.0002958981,0.0006512987,0.0002765083,0.0004973178,0.000381951,0.0002392836,0.001739553,0.0008051597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009488004,"about_ca_system_score_gemma":0.001109711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001279633,"about_ca_topic_score_gemma":0.001726374,"domain_scores_codex":[0.9997931,0.00006540995,0.00001435305,0.00005284923,0.00003274862,0.0000415291],"domain_scores_gemma":[0.9997658,0.00002332638,0.00003832287,0.00001800454,0.00001713908,0.0001372947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5321897,0.08577164,0.02138004,0.001158661,0.001860579,0.001211647,0.0003854737,0.004953074,0.1614707,0.000187043,0.007172159,0.1822594],"study_design_scores_gemma":[0.2226681,0.6974756,0.04360189,0.00006586501,0.0009062708,0.001428115,0.0001376075,0.003803463,0.023538,0.0002157648,0.006097144,0.00006227624],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971083,0.00104282,0.0001758528,0.0001039381,0.00002718924,0.0003588287,0.0003341683,0.00003110796,0.000817742],"genre_scores_gemma":[0.9972687,0.000522982,0.0003936378,0.0001617458,0.00004739277,0.0003147937,0.0005390789,0.00001053018,0.0007410738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002467735,"threshold_uncertainty_score":0.008255363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01232018435498204,"score_gpt":0.3024308497985526,"score_spread":0.2901106654435706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}