{"id":"W4200320859","doi":"10.3389/fnins.2021.790546","title":"In vivo Evidence for Brain Region-Specific Molecular Interactions Between Cannabinoid and Orexin Receptors","year":2021,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; College of Pharmacy and Nutrition, University of Saskatchewan; University of Saskatchewan","keywords":"Orexin; Orexin receptor; Cannabinoid receptor; Colocalization; Cannabinoid; Neuroscience; Endocannabinoid system; Cannabinoid receptor antagonist; Pharmacology; Agonist; Chemistry; Receptor; Biology; Internal medicine; Medicine; Neuropeptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002170611,0.0003821079,0.0002479964,0.0002759397,0.0002103912,0.0002673531,0.0003212941,0.0003409245,0.002618368],"category_scores_gemma":[0.0001797877,0.0002854801,0.0003446236,0.00009929352,0.000285442,0.0002843897,0.0002571317,0.0008112257,0.0005861123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004468145,"about_ca_system_score_gemma":0.0002411512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001098989,"about_ca_topic_score_gemma":0.00205927,"domain_scores_codex":[0.9998098,0.00002692203,0.00001027808,0.00005943719,0.00004433634,0.00004926746],"domain_scores_gemma":[0.9998922,0.00001684221,0.00002983781,0.00001459737,0.00001320073,0.00003330369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002401662,0.00003175245,0.0001623354,0.00002819654,0.00001297681,0.00005238885,0.000008461165,0.0000111071,0.9983759,0.000196003,0.00005382906,0.0008268869],"study_design_scores_gemma":[0.0001470623,0.001623486,0.04111402,0.00003893308,0.0001236508,0.001958483,0.0001108102,0.0008130312,0.9455911,0.0004670066,0.007992875,0.00001950838],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816854,0.005755668,0.006668158,0.0004352521,0.0001097539,0.00005435021,0.0005789025,0.00007694453,0.004635559],"genre_scores_gemma":[0.9744912,0.004211249,0.008085065,0.0002809232,0.00007140851,0.000143425,0.001401768,0.00003587982,0.01127912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002618368,"threshold_uncertainty_score":0.00875932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1029206971175707,"score_gpt":0.3552371581017499,"score_spread":0.2523164609841793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}