{"id":"W4200322694","doi":"10.1096/fj.202100497rr","title":"Human and mouse muscle transcriptomic analyses identify insulin receptor mRNA downregulation in hyperinsulinemia‐associated insulin resistance","year":2021,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; Canadian Institutes of Health Research; Novo Nordisk Fonden; Academy of Finland; British Heart Foundation; National Institutes of Health; Government of Canada; American Diabetes Association","keywords":"Hyperinsulinemia; Insulin resistance; Insulin receptor; Insulin; Downregulation and upregulation; IRS2; Insulin-like growth factor 1 receptor; Transcriptome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003718283,0.0001446309,0.0001822223,0.00005704257,0.0002770752,0.00005339074,0.0001675929,0.0001579062,0.00007991771],"category_scores_gemma":[0.0001530694,0.0001201319,0.00009694223,0.0001822391,0.0001207871,0.00001357573,0.00004795854,0.0002926792,0.000003947826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002647838,"about_ca_system_score_gemma":0.00008596462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002473906,"about_ca_topic_score_gemma":0.0007033002,"domain_scores_codex":[0.9987501,0.0003284075,0.0003308069,0.0002469012,0.0001179998,0.0002257764],"domain_scores_gemma":[0.9994373,0.00001854709,0.0001482258,0.0002233914,0.0001007024,0.00007178662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001461787,0.00009664883,0.001400673,0.000008604062,0.00006284515,0.000006663186,0.0001992066,0.0002917027,0.9966494,0.00002060039,0.0005374025,0.000580111],"study_design_scores_gemma":[0.003229732,0.0001171019,0.3415426,0.00005353201,0.00005664822,0.00002145478,0.0008732532,0.0000826478,0.6516416,0.0008277705,0.001244231,0.0003093996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950806,0.004030359,0.00006909025,0.0004163283,0.00008781251,0.00007538007,0.00002428624,0.000008350985,0.0002077942],"genre_scores_gemma":[0.9974068,0.001352492,0.0001046632,0.0002676632,0.0001300165,0.000005561292,0.0001255419,0.00001611171,0.0005911725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3450077,"threshold_uncertainty_score":0.4898835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02292047881097587,"score_gpt":0.2930487527948618,"score_spread":0.2701282739838859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}