{"id":"W4200325010","doi":"10.1136/jitc-2021-003439","title":"Early disappearance of tumor antigen-reactive T cells from peripheral blood correlates with superior clinical outcomes in melanoma under anti-PD-1 therapy","year":2021,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences North","funders":"Medizinischen Fakultät, Eberhard Karls Universität Tübingen; Klaus Tschira Stiftung; Eberhard Karls Universität Tübingen; Merck Sharp and Dohme; Bristol-Myers Squibb","keywords":"Medicine; Peripheral blood; Melanoma; Antigen; Peripheral; Metastatic melanoma; Immunology; Oncology; Internal medicine; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002644132,0.0002051076,0.0003687234,0.0002024031,0.000172377,0.0003845779,0.00009482841,0.0002461791,0.001354231],"category_scores_gemma":[0.0005996473,0.00011495,0.0001190008,0.0001370182,0.0001610463,0.0001906797,0.0001808521,0.0006080426,0.0003174809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001351558,"about_ca_system_score_gemma":0.0001063498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001225017,"about_ca_topic_score_gemma":0.00009855274,"domain_scores_codex":[0.9998806,0.00002215869,0.000009704633,0.00004296648,0.00001841251,0.00002633873],"domain_scores_gemma":[0.9995652,0.0001104915,0.0001154436,0.00003982423,0.00004101752,0.0001280486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01210767,0.0009409824,0.6261475,0.0001777055,0.00009107072,0.0008147233,0.0004092038,0.0006299468,0.3215575,0.00008659221,0.0005197488,0.03651736],"study_design_scores_gemma":[0.0002318304,0.01085359,0.9524561,0.00002364433,0.0001704523,0.003074316,0.0001586922,0.00121536,0.02984578,0.00010142,0.001856339,0.00001260153],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990735,0.0002417118,0.0001682041,0.000009091136,0.000004942921,0.0000158912,0.00007255345,0.000007234034,0.0004068746],"genre_scores_gemma":[0.999373,0.00006128404,0.0001061935,0.00002046732,0.000007692737,0.00002019567,0.0002066667,0.000003106197,0.0002013605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001354231,"threshold_uncertainty_score":0.004530311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02305420118363625,"score_gpt":0.3329098830996952,"score_spread":0.3098556819160589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}