{"id":"W4200335969","doi":"10.1016/j.xphs.2021.12.014","title":"Selective Targeting of the Novel CK-10 Nanoparticles to the MDA-MB-231 Breast Cancer Cells","year":2021,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"CancerCare Manitoba","funders":"","keywords":"PLGA; Poloxamer; Zeta potential; Chemistry; Nanoparticle; Poloxamer 407; Amphiphile; Dynamic light scattering; MTT assay; Chromatography; Nanotechnology; Materials science; Biochemistry; Cell growth; Polymer; Copolymer; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001261157,0.0002572661,0.0001759694,0.0001342133,0.0001228196,0.0002395756,0.0001684747,0.0003061812,0.0007550807],"category_scores_gemma":[0.00009898505,0.0001482866,0.0001441305,0.00007969778,0.0001694642,0.0001864715,0.0001361842,0.0002742454,0.0002012281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003946042,"about_ca_system_score_gemma":0.0002602949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001644494,"about_ca_topic_score_gemma":0.003176294,"domain_scores_codex":[0.9999067,0.000007814787,0.000005014378,0.00002351417,0.00002476025,0.00003215179],"domain_scores_gemma":[0.9999645,0.000008343687,0.000007021828,0.0000026029,0.000009441985,0.000008131051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004266451,0.000009258526,0.00005314653,0.00003475739,0.000002503315,0.00003240363,0.000009662038,0.0000822503,0.9984145,0.00007149929,0.00006098553,0.001186417],"study_design_scores_gemma":[0.000004269743,0.00005717419,0.0005344628,0.000002906809,0.000007219061,0.00009739312,0.000009054678,0.0009114459,0.997076,0.00001134195,0.001286171,0.000002498574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985097,0.002934459,0.007488742,0.0002033171,0.00007963297,0.00004024618,0.00014797,0.00008846045,0.003920096],"genre_scores_gemma":[0.9877915,0.001608799,0.005186067,0.00009122587,0.00001173084,0.00004163675,0.0001487349,0.00001638294,0.00510382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001644494,"threshold_uncertainty_score":0.003269851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03497713140544643,"score_gpt":0.3317886485186837,"score_spread":0.2968115171132373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}