{"id":"W4200336763","doi":"10.1016/j.ebiom.2021.103771","title":"Interaction between dolutegravir and folate transporters and receptor in human and rodent placenta","year":2021,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University Health Network; Toronto Rehabilitation Institute; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Drug Abuse Treatment Clinical Trials Network; National Institutes of Health; Canadian Institutes of Health Research; Ontario HIV Treatment Network","keywords":"Dolutegravir; Folate receptor; Placenta; Context (archaeology); Transporter; Biology; Solute carrier family; Pregnancy; Pharmacology; Fetus; Virology; Cancer cell; Gene; Biochemistry; Cancer; Genetics; Human immunodeficiency virus (HIV); Viral load","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002940776,0.0001161011,0.0003012855,0.0002391804,0.00006334434,0.00002302674,0.00002532345,0.00008010857,0.0001047979],"category_scores_gemma":[0.00002929267,0.00009204901,0.00001903838,0.0002091515,0.0001424701,0.00009763955,0.00003053763,0.00031741,0.0000024528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005077032,"about_ca_system_score_gemma":0.00003203921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002030226,"about_ca_topic_score_gemma":0.0001089308,"domain_scores_codex":[0.9990438,0.00003961167,0.0002445849,0.0002643893,0.0002023005,0.0002052929],"domain_scores_gemma":[0.9995375,0.00005267709,0.00003292808,0.0001152284,0.00004259356,0.0002190186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000309404,0.0001511826,0.5882562,0.0003966946,0.0001667331,0.0008195163,0.002993657,5.302073e-8,0.2841235,0.00003232693,0.001619274,0.1211315],"study_design_scores_gemma":[0.007350541,0.001361054,0.9605724,0.0007368185,0.0001380414,0.0005568325,0.002278618,0.0000406889,0.00657516,0.0001088858,0.02011135,0.0001696574],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935256,0.001949907,0.00001921792,0.003929287,0.000095549,0.0001724398,0.000007708669,0.00001341403,0.0002869166],"genre_scores_gemma":[0.9967445,0.001524249,0.0001277202,0.0001631321,0.0001987029,0.000003643569,0.0001272957,0.00001353151,0.001097185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3723161,"threshold_uncertainty_score":0.375365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02956678725880207,"score_gpt":0.3388764302610471,"score_spread":0.309309643002245,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}