{"id":"W4200336780","doi":"10.3390/molecules27010001","title":"Three of a Kind: Control of the Expression of Liver-Expressed Antimicrobial Peptide 2 (LEAP2) by the Endocannabinoidome and the Gut Microbiome","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"Dietary Effects on Health","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Impact; Université Laval","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Ileum; Internal medicine; Endocrinology; Biology; Endocannabinoid system; Small intestine; Ghrelin; Leptin; Energy homeostasis; Microbiome; Peptide YY; Receptor; Neuropeptide Y receptor; Neuropeptide; Medicine; Obesity; Bioinformatics; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003551043,0.0001650768,0.0005244954,0.00003890247,0.00007216298,0.000009178989,0.0002729156,0.00007304153,0.00003695253],"category_scores_gemma":[0.0003087619,0.00007842963,0.000190135,0.0001842085,0.0006554046,0.00003150216,0.0001574844,0.0001969631,0.000001254506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001358782,"about_ca_system_score_gemma":0.0002160508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007082524,"about_ca_topic_score_gemma":0.00009061651,"domain_scores_codex":[0.9985548,0.0003202549,0.0004144266,0.0002242226,0.0002706734,0.0002155877],"domain_scores_gemma":[0.9983761,0.0003972186,0.0003284372,0.000678207,0.0001582771,0.00006175014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007637265,0.0001446079,0.0009114259,0.0003611764,0.00008610111,0.000009659458,0.0005444615,0.000009865709,0.9794674,0.0001567225,0.01679729,0.0007475742],"study_design_scores_gemma":[0.006542306,0.0001767928,0.01277577,0.0005423883,0.0002186419,0.00005113395,0.00009683128,0.0001598099,0.9776112,0.000123315,0.001622545,0.00007927581],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844448,0.004685321,0.0009409644,0.008260676,0.00009500521,0.001088038,0.0001678862,0.00001116681,0.0003061605],"genre_scores_gemma":[0.9979783,0.0002065759,0.0003744356,0.001105464,0.00004054016,0.0000129163,0.0000119817,0.00002065225,0.0002491241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01517474,"threshold_uncertainty_score":0.3198267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005972415786906521,"score_gpt":0.2214702109922577,"score_spread":0.2154977952053512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}