{"id":"W4200344199","doi":"10.1101/2021.12.04.21267242","title":"Asymptomatic carriers of the p.A53T SNCA mutation: data from the PPMI study","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Biochemical Analysis and Sensing Techniques","field":"Nursing","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Horizon 2020 Framework Programme; FP7 Health; Genentech; European Commission; Hellenic Foundation for Research and Innovation; Teva Pharmaceutical Industries; Biogen; GlaxoSmithKline; Servier; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; Michael J. Fox Foundation for Parkinson's Research","keywords":"Asymptomatic; Medicine; Internal medicine; Olfaction; Parkinson's disease; Asymptomatic carrier; Anxiety; Montreal Cognitive Assessment; Gastroenterology; Disease; Psychiatry; Cognitive impairment; Psychology; Neuroscience","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000613693,0.0003081456,0.0006394674,0.001203183,0.0003294723,0.0005926195,0.0003634598,0.000447124,0.001921342],"category_scores_gemma":[0.001952661,0.0001536714,0.0004028497,0.001139354,0.0002429999,0.0004617689,0.0005372605,0.0002985596,0.0003313361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001761894,"about_ca_system_score_gemma":0.0001410882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002347144,"about_ca_topic_score_gemma":0.001880661,"domain_scores_codex":[0.9993865,0.0001157099,0.0001134665,0.0002009051,0.0001336948,0.0000496694],"domain_scores_gemma":[0.9985442,0.0003274281,0.0005741984,0.0001238767,0.0002026874,0.000227585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008134209,0.00005042283,0.9962029,0.00004351971,0.0001318995,0.0003699031,0.0001092594,0.00001995374,0.0003920472,0.00001787224,0.0001923866,0.001656479],"study_design_scores_gemma":[0.00004101961,0.0002219281,0.9985984,0.00000774741,0.00008166411,0.000590264,0.0001268149,0.00004693298,0.00006110127,0.0000179055,0.0002024547,0.000003744313],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998091,0.0004185917,0.00003859203,0.00001425464,0.000003781689,0.00001363798,0.001119953,0.000002000839,0.0002982211],"genre_scores_gemma":[0.997947,0.0001093141,0.00003350669,0.00001677246,0.00001129209,0.00001622665,0.001784947,0.000001766722,0.00007916657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002347144,"threshold_uncertainty_score":0.006427586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0506474495453977,"score_gpt":0.3094143332013511,"score_spread":0.2587668836559534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}