{"id":"W4200345348","doi":"10.3233/jpd-212714","title":"Safety, Pharmacokinetics, and Pharmacodynamics of Oral Venglustat in Patients with Parkinson’s Disease and a GBA Mutation: Results from Part 1 of the Randomized, Double-Blinded, Placebo-Controlled MOVES-PD Trial","year":2021,"lang":"en","type":"article","venue":"Journal of Parkinson s Disease","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"UCB Pharma; Sanofi Genzyme; Parkinsonfonden; Allergan; National Institutes of Health; H. Lundbeck A/S; Eisai; Acorda Therapeutics; US WorldMeds; Sunovion; Weston Brain Institute; Israel Science Foundation; Boston Scientific Corporation; International Parkinson and Movement Disorder Society; Biogen; European Commission; U.S. Department of Defense; Sanofi; Pfizer; American Parkinson Disease Association; National Institute of Neurological Disorders and Stroke; Teva Pharmaceutical Industries; National Parkinson Foundation","keywords":"Parkinson's disease; Pharmacodynamics; Medicine; Pharmacokinetics; Placebo; Double blinded; Randomized controlled trial; Pharmacology; Disease; Internal medicine; Pathology; Alternative medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001408607,0.0009334721,0.001902011,0.0001929847,0.0002757724,0.0005662518,0.0004623023,0.001089989,0.002933152],"category_scores_gemma":[0.001325615,0.0004207645,0.001232907,0.0002427887,0.0006765453,0.000593647,0.0002563577,0.001142773,0.0004243091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005540705,"about_ca_system_score_gemma":0.000612785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005947591,"about_ca_topic_score_gemma":0.001637494,"domain_scores_codex":[0.9994708,0.0003099189,0.00004213789,0.00008822804,0.0000414808,0.0000475054],"domain_scores_gemma":[0.9992688,0.0001666542,0.0002560197,0.00005437387,0.00006506223,0.0001891429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9778386,0.002163739,0.003021532,0.0004247751,0.001126518,0.00003926312,0.00006776267,0.0003109959,0.003654107,0.00004034015,0.0004545743,0.01085772],"study_design_scores_gemma":[0.8618104,0.1153229,0.01885347,0.00004595795,0.001482769,0.0001112271,0.00006068313,0.000471184,0.00096925,0.0001044,0.0007415933,0.00002611403],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964619,0.001856128,0.0001070981,0.0001265828,0.00005006598,0.000341469,0.0004312684,0.00001942913,0.0006062139],"genre_scores_gemma":[0.9969068,0.0008641049,0.0002925428,0.0002209506,0.00007314672,0.000372879,0.0006883551,0.000007155017,0.000573957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002933152,"threshold_uncertainty_score":0.009812355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0198419044361397,"score_gpt":0.2995588267276537,"score_spread":0.279716922291514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}