{"id":"W4200345348","doi":"10.3233/jpd-212714","title":"Safety, Pharmacokinetics, and Pharmacodynamics of Oral Venglustat in Patients with Parkinson’s Disease and a GBA Mutation: Results from Part 1 of the Randomized, Double-Blinded, Placebo-Controlled MOVES-PD Trial","year":2021,"lang":"en","type":"article","venue":"Journal of Parkinson s Disease","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"UCB Pharma; Sanofi Genzyme; Parkinsonfonden; Allergan; National Institutes of Health; H. Lundbeck A/S; Eisai; Acorda Therapeutics; US WorldMeds; Sunovion; Weston Brain Institute; Israel Science Foundation; Boston Scientific Corporation; International Parkinson and Movement Disorder Society; Biogen; European Commission; U.S. Department of Defense; Sanofi; Pfizer; American Parkinson Disease Association; National Institute of Neurological Disorders and Stroke; Teva Pharmaceutical Industries; National Parkinson Foundation","keywords":"Parkinson's disease; Pharmacodynamics; Medicine; Pharmacokinetics; Placebo; Double blinded; Randomized controlled trial; Pharmacology; Disease; Internal medicine; Pathology; Alternative medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00115882,0.0002836156,0.001344514,0.0002346359,0.0000687557,0.00004339421,0.0001816003,0.00006849149,0.00007622591],"category_scores_gemma":[0.001747027,0.0001822225,0.0003570145,0.0003945788,0.0003882738,0.0002002108,0.0001210613,0.0004427634,4.266952e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000117127,"about_ca_system_score_gemma":0.0009030511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006688778,"about_ca_topic_score_gemma":0.00003691642,"domain_scores_codex":[0.9956939,0.0008295384,0.001514547,0.0003518571,0.001315909,0.000294238],"domain_scores_gemma":[0.9962918,0.0007313943,0.001150559,0.0003200537,0.0008191565,0.0006870099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9289828,0.001733713,0.06457049,0.0001672086,0.0008201943,0.0006203085,0.0003661261,0.0006372626,0.00003461475,0.000009930601,0.0001694838,0.001887846],"study_design_scores_gemma":[0.8784564,0.0003475113,0.1136879,0.0004208788,0.001955096,0.000008000798,0.0001553922,0.003600048,0.0001065295,0.000168012,0.0009349394,0.0001593189],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907268,0.004208933,0.00005329114,0.001452036,0.0002907327,0.002701931,0.0004976813,0.000005330387,0.00006322963],"genre_scores_gemma":[0.9979104,0.001410121,0.0001670658,0.0001405396,0.0001628109,0.00004247716,0.00007417976,0.00003309099,0.00005929583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05052647,"threshold_uncertainty_score":0.7430819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0198419044361397,"score_gpt":0.2995588267276537,"score_spread":0.279716922291514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}