{"id":"W4200349633","doi":"10.1016/j.ccell.2021.12.005","title":"GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity","year":2021,"lang":"en","type":"article","venue":"Cancer Cell","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":163,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Christian Doppler Forschungsgesellschaft; Deutsche Krebshilfe; National Cancer Institute; Entertainment Industry Foundation; Damon Runyon Cancer Research Foundation; Virginia and D.K. Ludwig Fund for Cancer Research; Stanford University; Canadian Institute for Advanced Research; Cancer Research Institute; Österreichische Nationalstiftung für Forschung, Technologie und Entwicklung; Alex's Lemonade Stand Foundation for Childhood Cancer; Burroughs Wellcome Fund; National Institutes of Health; Canada Research Chairs; Howard Hughes Medical Institute","keywords":"Chimeric antigen receptor; Neuroblastoma; Antigen; Cancer research; Biology; Immune system; Cell culture; Cell biology; Immunology; T cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002974878,0.0003012985,0.0006048601,0.00006243127,0.0001515649,0.0000469725,0.0001820902,0.0001787679,0.001186619],"category_scores_gemma":[0.00006275856,0.0002918047,0.0003181444,0.000271296,0.0001208146,0.0001082505,0.0001474001,0.0003932478,0.00005155759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005021814,"about_ca_system_score_gemma":0.0008008354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001853679,"about_ca_topic_score_gemma":0.0006157715,"domain_scores_codex":[0.9975947,0.0001388717,0.0002647711,0.000726849,0.0005703963,0.0007044663],"domain_scores_gemma":[0.9981169,0.0001432354,0.0001186184,0.0007219002,0.0004552011,0.0004442025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001009067,0.0003541379,0.002625834,0.0003546971,0.00009817336,0.0001836637,0.000236452,0.00007051988,0.9770472,0.000001108847,0.002081895,0.01593723],"study_design_scores_gemma":[0.002804407,0.0002465268,0.008307863,0.00008274629,0.00007317049,0.0000114832,0.0000659931,0.001527246,0.9726931,0.00001111843,0.01390716,0.0002692061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930279,0.0006004563,0.0006272178,0.0007791837,0.0008287923,0.001060486,0.0001013313,0.00009858576,0.002876091],"genre_scores_gemma":[0.9824417,0.002359305,0.0003767485,0.001522069,0.000677397,0.0001007827,0.00003953997,0.0000921859,0.01239022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01566802,"threshold_uncertainty_score":0.9999534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02552886023817936,"score_gpt":0.3040762354558255,"score_spread":0.2785473752176461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}