{"id":"W4200349790","doi":"10.1038/s41467-021-27055-4","title":"A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill Genome Centre; McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Cancer Research Society; Canadian Institutes of Health Research; Fondation de l'Hôpital Général de Montréal; National Natural Science Foundation of China; McGill University","keywords":"Enhancer; SOX2; Biology; Chromatin; Activator (genetics); Cancer research; Transcription factor; Oncogene; CRISPR; Cell biology; Molecular biology; Cancer; Genetics; Gene; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001105136,0.0002372683,0.0002569795,0.0002378592,0.0001579007,0.0003144722,0.0001600292,0.0002247176,0.002196564],"category_scores_gemma":[0.0001660513,0.0001840771,0.0001870165,0.0001159996,0.0002427516,0.0001486589,0.0003514399,0.0004128247,0.0006127537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002147491,"about_ca_system_score_gemma":0.0002987757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000520391,"about_ca_topic_score_gemma":0.001359938,"domain_scores_codex":[0.9998419,0.0000202332,0.0000188908,0.00003165276,0.00004842976,0.00003894778],"domain_scores_gemma":[0.999733,0.00006065097,0.00005469549,0.0000385855,0.00002323073,0.00008981876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003367183,0.00001178918,0.0005499238,0.00001095359,0.000002410902,0.00009726122,0.000004614579,0.0000271417,0.9986823,0.00005604338,0.00001503666,0.0005088489],"study_design_scores_gemma":[0.000008063476,0.00009537915,0.01426329,0.000004917751,0.00001008888,0.0007849425,0.00003223383,0.0007693486,0.982299,0.00005363369,0.001675254,0.000003760415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956261,0.0004817761,0.002159512,0.00005573973,0.00001411586,0.0000196541,0.0003351021,0.0001112767,0.001196711],"genre_scores_gemma":[0.9973525,0.0001469222,0.0008490642,0.00002253065,0.000002963563,0.00001170691,0.0003444012,0.00002529527,0.001244743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002196564,"threshold_uncertainty_score":0.00734818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0125978908024423,"score_gpt":0.3053365178321263,"score_spread":0.292738627029684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}