{"id":"W4200351251","doi":"10.30824/2112-7","title":"Targeting C-domain of Angiotensin Converting Enzyme and Nerprilysin as a Potential New Therapeutic Strategy in Hypertension","year":2021,"lang":"en","type":"article","venue":"Hypertension News","topic":"Computational Drug Discovery Methods","field":"Computer Science","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"McGill University","keywords":"Angiotensin-converting enzyme; Domain (mathematical analysis); Renin–angiotensin system; Medicine; Pharmacology; Internal medicine; Blood pressure; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004659969,0.0002970052,0.0004692068,0.0001614186,0.000142116,0.000908362,0.0003723522,0.0007039386,0.002782102],"category_scores_gemma":[0.0006549362,0.0001332653,0.0004107792,0.0001527356,0.0002210057,0.0007419091,0.0002242386,0.00171507,0.0009402551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003087119,"about_ca_system_score_gemma":0.0003334599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003286708,"about_ca_topic_score_gemma":0.0006893822,"domain_scores_codex":[0.9998796,0.00002498292,0.000009616035,0.00001406646,0.0000517002,0.00001995948],"domain_scores_gemma":[0.9998137,0.00008392731,0.00001897731,0.000009393539,0.00004069121,0.00003336256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002990321,0.0005482409,0.002635347,0.002274899,0.0003565183,0.001081752,0.00008942719,0.007104139,0.1003294,0.03084975,0.1623078,0.6894324],"study_design_scores_gemma":[0.001231499,0.001812252,0.004655814,0.0005984533,0.0007341058,0.002651845,0.0001759407,0.06579829,0.1249408,0.03046259,0.7668104,0.0001279772],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1333805,0.6140498,0.05906058,0.1134423,0.03613225,0.0001383748,0.00146519,0.001917906,0.04041309],"genre_scores_gemma":[0.4068907,0.4718989,0.03704901,0.02689874,0.009005293,0.000173394,0.00234004,0.0001818778,0.04556207],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002782102,"threshold_uncertainty_score":0.009307086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03070557300801876,"score_gpt":0.2695646473420241,"score_spread":0.2388590743340053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}