{"id":"W4200361575","doi":"10.3390/ph14121316","title":"Potential of Fatty Acid Amide Hydrolase (FAAH), Monoacylglycerol Lipase (MAGL), and Diacylglycerol Lipase (DAGL) Enzymes as Targets for Obesity Treatment: A Narrative Review","year":2021,"lang":"en","type":"review","venue":"Pharmaceuticals","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; University of New Brunswick; Centre for Addiction and Mental Health","funders":"","keywords":"Monoacylglycerol lipase; Fatty acid amide hydrolase; Endocannabinoid system; Diacylglycerol lipase; Anandamide; Lipase; Pharmacology; Biology; Biochemistry; Medicine; Cannabinoid receptor; Enzyme; Receptor; Agonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.001091787,0.001288266,0.006156008,0.0003905861,0.0002965495,0.00009943797,0.0003702055,0.0005399678,0.001496786],"category_scores_gemma":[0.001351648,0.0009722636,0.002383099,0.0007130528,0.0005216298,0.0001819473,0.0003502872,0.0009616301,0.00006340646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004989999,"about_ca_system_score_gemma":0.002031043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007609189,"about_ca_topic_score_gemma":0.000007169162,"domain_scores_codex":[0.9934953,0.0009639732,0.001856477,0.001551496,0.0009419401,0.001190741],"domain_scores_gemma":[0.9956363,0.0003006009,0.0007092188,0.001100767,0.0007317249,0.001521425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005289699,0.002104026,0.00001644675,0.1524934,0.002536964,0.0009080144,0.0003175623,4.784189e-7,0.0003502176,0.00008804214,0.02752026,0.8131357],"study_design_scores_gemma":[0.004277603,0.001217535,0.000007667872,0.02608214,0.01057985,0.0006867399,0.00008291812,0.0001056221,0.006522445,0.00002546294,0.9496689,0.0007431316],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0005559119,0.9851124,0.00008070471,0.002826505,0.0002749495,0.009409147,0.001413601,0.00008062731,0.0002461148],"genre_scores_gemma":[0.0005229945,0.9891307,0.0002244706,0.001019028,0.000628075,0.00332018,0.0009079824,0.0001848768,0.004061639],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9221486,"threshold_uncertainty_score":0.9999869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06619786433126904,"score_gpt":0.4423868708139847,"score_spread":0.3761890064827157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}