{"id":"W4200361734","doi":"10.1093/ofid/ofab466.1176","title":"982. Effect of Hepatic Impairment on the Safety and Pharmacokinetics of Rezafungin","year":2021,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Altasciences (Canada)","funders":"","keywords":"Medicine; Tolerability; Caspofungin; Pharmacokinetics; Internal medicine; Echinocandin; Population; Body mass index; Antifungal; Adverse effect; Gastroenterology; Fluconazole","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000240538,0.0001207478,0.0003748697,0.00002669932,0.00008892378,0.00001751134,0.00008199549,0.00003008498,0.0004067069],"category_scores_gemma":[0.0004334644,0.00007442076,0.0001199937,0.0001650171,0.0001225277,0.00004555232,0.0001379589,0.00008344695,0.000005298713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003959233,"about_ca_system_score_gemma":0.0001120769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005859231,"about_ca_topic_score_gemma":0.00003953752,"domain_scores_codex":[0.9990499,0.0001574887,0.0002499563,0.0001920454,0.0001990482,0.0001515671],"domain_scores_gemma":[0.998924,0.0004292019,0.00009915053,0.0003510362,0.0001024491,0.0000941605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001630228,0.000508119,0.9873675,0.0004502711,0.0001468782,0.00001658289,0.00003899022,0.00001030072,0.002875569,0.000922943,0.001927739,0.004104911],"study_design_scores_gemma":[0.003733236,0.003281004,0.9311922,0.0005940504,0.0005819255,0.00001867418,0.0001613696,0.0001919077,0.05772902,0.0004532298,0.001912538,0.0001508711],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988388,0.001050491,0.00002382508,0.0007623236,0.00006237741,0.0007828588,0.00009077643,0.00001295774,0.00882638],"genre_scores_gemma":[0.9984655,0.0006328408,0.000008210127,0.0003895173,0.00001355439,0.00001849721,0.00002400204,0.0000113452,0.0004365394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05617529,"threshold_uncertainty_score":0.4453155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008115522000828962,"score_gpt":0.2945352747176639,"score_spread":0.286419752716835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}