{"id":"W4200361734","doi":"10.1093/ofid/ofab466.1176","title":"982. Effect of Hepatic Impairment on the Safety and Pharmacokinetics of Rezafungin","year":2021,"lang":"en","type":"article","venue":"Open Forum Infectious Diseases","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Altasciences (Canada)","funders":"","keywords":"Medicine; Tolerability; Caspofungin; Pharmacokinetics; Internal medicine; Echinocandin; Population; Body mass index; Antifungal; Adverse effect; Gastroenterology; Fluconazole","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003743578,0.000180148,0.0002696961,0.0001007357,0.00009863585,0.0002293997,0.0001023987,0.000172186,0.003165673],"category_scores_gemma":[0.0004108822,0.00007156054,0.0002004992,0.0001062933,0.0001320825,0.0001476825,0.00008315595,0.0002783004,0.0004821185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001597058,"about_ca_system_score_gemma":0.0001372968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005946074,"about_ca_topic_score_gemma":0.0005980765,"domain_scores_codex":[0.9998279,0.00007209487,0.00001346558,0.00002253842,0.00003512156,0.00002888685],"domain_scores_gemma":[0.9997112,0.0001044892,0.00008745601,0.00002595924,0.00003201509,0.00003874846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.1432333,0.003836628,0.1331471,0.00056415,0.0004218128,0.001838669,0.000157465,0.001611049,0.5066533,0.0002465128,0.001873393,0.2064165],"study_design_scores_gemma":[0.002801675,0.10332,0.6906462,0.0000671372,0.0004828393,0.003773771,0.0001583482,0.00509646,0.1830806,0.0001862057,0.01034979,0.00003696152],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970138,0.0009606909,0.0003530234,0.00004564086,0.00001139594,0.00005180006,0.0002779139,0.00001874586,0.001266861],"genre_scores_gemma":[0.9987915,0.0001634986,0.0001535019,0.00005158704,0.00001390437,0.00001722848,0.0001852148,0.000003818555,0.0006197066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003165673,"threshold_uncertainty_score":0.0105902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008115522000828962,"score_gpt":0.2945352747176639,"score_spread":0.286419752716835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}