{"id":"W4200362073","doi":"10.1101/2021.12.01.21267132","title":"Trans-ancestry genome-wide association study identifies novel genetic mechanisms in rheumatoid arthritis","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute","funders":"Instituto de Salud Carlos III; NIHR Maudsley Biomedical Research Centre; National Institutes of Health; Moonshot Research and Development Program; Kementerian Kesihatan Malaysia; Versus Arthritis; Kanae Foundation for the Promotion of Medical Science; Astellas Pharma; National Institute for Health and Care Research; Ministerio de Ciencia e Innovación; Vetenskapsrådet; Fonds National de la Recherche Luxembourg; King's College London; Qatar National Research Fund; Qatar Foundation; Department of Health and Social Care; Japan Agency for Medical Research and Development; South London and Maudsley NHS Foundation Trust; Japan Society for the Promotion of Science; Mochida Memorial Foundation for Medical and Pharmaceutical Research","keywords":"Genome-wide association study; Genetic association; Genetic genealogy; Biology; Rheumatoid arthritis; Genetics; Genetic architecture; Candidate gene; Computational biology; Evolutionary biology; Gene; Genotype; Single-nucleotide polymorphism; Medicine; Phenotype; Population; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00223062,0.0005798814,0.0007374918,0.001054449,0.0004860668,0.001252156,0.0003158995,0.0005350735,0.004577726],"category_scores_gemma":[0.003433625,0.0002277912,0.001278376,0.001350532,0.000392551,0.0003296128,0.0008073344,0.0008042407,0.0005413402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001266999,"about_ca_system_score_gemma":0.0002425046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001380496,"about_ca_topic_score_gemma":0.001568261,"domain_scores_codex":[0.9989328,0.0004778402,0.00008538555,0.0003086221,0.0001140932,0.00008134628],"domain_scores_gemma":[0.9981437,0.0006563134,0.0003738374,0.0004767092,0.0001841647,0.0001652632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002900739,0.0001356378,0.8887936,0.0002139049,0.004516096,0.001562148,0.0004091336,0.001214433,0.0547488,0.001112435,0.001382601,0.04301055],"study_design_scores_gemma":[0.0002081509,0.0004207888,0.9650789,0.00005003516,0.00396345,0.003812206,0.0003573023,0.007725638,0.01036799,0.003373337,0.004601806,0.00004031711],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841488,0.002720285,0.009980731,0.0004268846,0.00007329819,0.00001609268,0.001096478,0.0001781908,0.001359149],"genre_scores_gemma":[0.9962465,0.0003689198,0.00204781,0.00007624875,0.0000574579,0.000006994093,0.0005875214,0.00003105714,0.0005774372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004577726,"threshold_uncertainty_score":0.01531404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02462211877773814,"score_gpt":0.2666770522615599,"score_spread":0.2420549334838217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}