{"id":"W4200362073","doi":"10.1101/2021.12.01.21267132","title":"Trans-ancestry genome-wide association study identifies novel genetic mechanisms in rheumatoid arthritis","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute","funders":"Instituto de Salud Carlos III; NIHR Maudsley Biomedical Research Centre; National Institutes of Health; Moonshot Research and Development Program; Kementerian Kesihatan Malaysia; Versus Arthritis; Kanae Foundation for the Promotion of Medical Science; Astellas Pharma; National Institute for Health and Care Research; Ministerio de Ciencia e Innovación; Vetenskapsrådet; Fonds National de la Recherche Luxembourg; King's College London; Qatar National Research Fund; Qatar Foundation; Department of Health and Social Care; Japan Agency for Medical Research and Development; South London and Maudsley NHS Foundation Trust; Japan Society for the Promotion of Science; Mochida Memorial Foundation for Medical and Pharmaceutical Research","keywords":"Genome-wide association study; Genetic association; Genetic genealogy; Biology; Rheumatoid arthritis; Genetics; Genetic architecture; Candidate gene; Computational biology; Evolutionary biology; Gene; Genotype; Single-nucleotide polymorphism; Medicine; Phenotype; Population; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005088345,0.0004096209,0.001008824,0.0002098586,0.00007030267,0.0001512676,0.0001875562,0.0003568892,0.0002750739],"category_scores_gemma":[0.000279068,0.0004056982,0.000283554,0.0002239429,0.00002062625,0.00005926487,0.0001891281,0.0004306485,0.00002792588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008422372,"about_ca_system_score_gemma":0.0003591938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007785658,"about_ca_topic_score_gemma":0.002200094,"domain_scores_codex":[0.9970299,0.0001422798,0.0007987315,0.0008643651,0.0007579145,0.0004068252],"domain_scores_gemma":[0.9984949,0.0002110482,0.0003178785,0.0006729374,0.0001599799,0.0001432495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00002175192,0.003087483,0.9895774,0.0001530738,0.0005896692,0.001017248,0.002458405,0.0001252826,0.001288504,0.000005810738,0.000030113,0.001645323],"study_design_scores_gemma":[0.004365232,0.0001663351,0.9904159,0.0008379353,0.0001722142,0.00001870416,0.001277376,0.00002908748,0.002061394,0.0002192223,0.000131741,0.0003048493],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899753,0.005831559,0.0005756404,0.0008903162,0.0009405215,0.001477343,0.00004504106,0.00007736388,0.0001868553],"genre_scores_gemma":[0.9885067,0.008861085,0.001074215,0.0002152643,0.00008134121,0.0007957758,0.0001748118,0.00005423764,0.0002365708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00434348,"threshold_uncertainty_score":0.9998395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02462211877773814,"score_gpt":0.2666770522615599,"score_spread":0.2420549334838217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}