{"id":"W4200370142","doi":"10.1016/j.drudis.2021.12.012","title":"Therapeutic potential of targeting regulatory mechanisms of hepatic stellate cell activation in liver fibrosis","year":2021,"lang":"en","type":"review","venue":"Drug Discovery Today","topic":"Liver physiology and pathology","field":"Medicine","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; Children's Hospital Research Institute of Manitoba; CancerCare Manitoba; Impact","funders":"","keywords":"Hepatic stellate cell; Extracellular matrix; Hepatic fibrosis; Fibrosis; Liver fibrosis; Cancer research; Biology; Medicine; Cell biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004368767,0.000718586,0.001020504,0.001703217,0.0002150454,0.0008564876,0.0006851465,0.0009921154,0.003632987],"category_scores_gemma":[0.0004730925,0.0001751941,0.0004798927,0.001147988,0.0003603328,0.0009624872,0.0006223785,0.001812463,0.001726033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004043381,"about_ca_system_score_gemma":0.0005135454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003768981,"about_ca_topic_score_gemma":0.0008579693,"domain_scores_codex":[0.9998815,0.00002513623,0.00001447915,0.00002120401,0.00004207219,0.00001560402],"domain_scores_gemma":[0.9998463,0.00007295718,0.00001939817,0.000005648869,0.00003839634,0.00001720553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001096572,0.0001259627,0.00013884,0.01386839,0.00008938328,0.0002927929,0.00006375665,0.0006033978,0.005371934,0.007295693,0.02614955,0.9458908],"study_design_scores_gemma":[0.0000267952,0.000152146,0.0006509532,0.002565879,0.0001086122,0.001413123,0.00004106581,0.0001652374,0.001255286,0.003007171,0.9905933,0.00002053532],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001889789,0.9978358,0.0002231479,0.0002709981,0.0002477059,0.000005189819,0.00001918772,0.00000976706,0.001199204],"genre_scores_gemma":[0.001101735,0.9974682,0.0002519627,0.000209752,0.0001965547,0.000008587071,0.00003352379,0.000001915377,0.0007277477],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003632987,"threshold_uncertainty_score":0.01215357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01856563031246275,"score_gpt":0.2716041928286392,"score_spread":0.2530385625161764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}