{"id":"W4200371566","doi":"10.1111/imcb.12520","title":"The ICOS–ICOSL pathway tunes thymic selection","year":2021,"lang":"en","type":"article","venue":"Immunology and Cell Biology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research","keywords":"Negative selection; T cell; CD28; Cell biology; Central tolerance; Biology; Antigen; Co-stimulation; Population; Downregulation and upregulation; Immunology; T-cell receptor; Immune tolerance; Receptor; Immune system; Medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003891267,0.0004039482,0.0005311898,0.0001128266,0.001433087,0.00003910346,0.0004332041,0.001153823,0.0007756565],"category_scores_gemma":[0.0001214919,0.0002923692,0.0001671117,0.0002777315,0.001670664,0.0000825449,0.000382107,0.001020806,0.001200436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004144249,"about_ca_system_score_gemma":0.0002176393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001145195,"about_ca_topic_score_gemma":0.0001760488,"domain_scores_codex":[0.996565,0.001104677,0.000544672,0.0007553337,0.00002512973,0.001005213],"domain_scores_gemma":[0.9982626,0.0007401863,0.000225598,0.0005571247,0.000183068,0.00003144089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002301909,0.000180769,0.002335676,0.000009349012,0.0003520417,0.0000161319,0.0001629125,7.528281e-7,0.9607263,0.01210933,0.0009503345,0.02292619],"study_design_scores_gemma":[0.001248227,0.000355233,0.001131324,0.00000627483,0.00004221013,0.0005867836,0.0004805464,0.000002459539,0.6237527,0.00226751,0.3698756,0.0002511425],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8756348,0.1116184,0.0001123152,0.001624265,0.003638585,0.0002201998,0.00002404598,0.0001992408,0.006928129],"genre_scores_gemma":[0.9715409,0.009207302,0.00004786547,0.0005100869,0.00008068645,0.00006963887,0.0002076067,0.00003054878,0.01830537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3689252,"threshold_uncertainty_score":0.9999529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006843658931267712,"score_gpt":0.201707198568882,"score_spread":0.1948635396376143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}