{"id":"W4200380053","doi":"10.1186/s13567-021-01014-9","title":"Prototheca spp. induce an inflammatory response via mtROS-mediated activation of NF-κB and NLRP3 inflammasome pathways in bovine mammary epithelial cell cultures","year":2021,"lang":"en","type":"article","venue":"Veterinary Research","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Natural Science Foundation of China","keywords":"Inflammasome; Biology; Proinflammatory cytokine; Western blot; NF-κB; Cytokine; Microbiology; Pathogenesis; Mitochondrion; Inflammation; Cell biology; Immunology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003021121,0.0003467489,0.0004095317,0.0003119831,0.0002494322,0.0003339897,0.0001954521,0.00035568,0.001239243],"category_scores_gemma":[0.0001452339,0.0002233542,0.0004617936,0.0003176378,0.0001835615,0.0002620921,0.0003064733,0.0008272763,0.0004177309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003445124,"about_ca_system_score_gemma":0.0003724156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002073812,"about_ca_topic_score_gemma":0.002222673,"domain_scores_codex":[0.9996446,0.00004506704,0.00004900377,0.00007385517,0.00009702811,0.00009050607],"domain_scores_gemma":[0.9998932,0.00001852986,0.00003041914,0.0000165269,0.00002238744,0.00001889101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000509258,0.00009628452,0.0007371173,0.0001599597,0.000008936548,0.0001979447,0.00009293493,0.0000645531,0.9966833,0.00005837011,0.00009399008,0.001297425],"study_design_scores_gemma":[0.0001131557,0.001781253,0.03436679,0.00007352189,0.00006320238,0.001416441,0.0004523285,0.003033736,0.9492781,0.0002219606,0.009176409,0.00002311766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870908,0.005537829,0.002637362,0.0002616312,0.00009507417,0.0001007797,0.001307577,0.00008910734,0.002879897],"genre_scores_gemma":[0.9881038,0.0023219,0.003385161,0.0001579749,0.00004753754,0.000165034,0.001732534,0.00001311913,0.004072893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002073812,"threshold_uncertainty_score":0.004145682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03360367835872315,"score_gpt":0.3144499169724552,"score_spread":0.280846238613732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}