{"id":"W4200381606","doi":"10.3389/fonc.2021.767697","title":"Patient-Derived Explants as a Precision Medicine Patient-Proximal Testing Platform Informing Cancer Management","year":2021,"lang":"en","type":"review","venue":"Frontiers in Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Partenariat Canadien Contre Le Cancer; Australian Government; Cancer Australia; PA Research Foundation","keywords":"Medicine; Precision medicine; Personalized medicine; Cancer; Longevity; Patient care; Bioinformatics; Medical physics; Computational biology; Internal medicine; Pathology; Biology; Nursing","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001813037,0.0004760185,0.001447243,0.0002778843,0.00008909108,0.00002170634,0.0003323703,0.000647656,0.00006137202],"category_scores_gemma":[0.0004529114,0.0004302943,0.0001920792,0.0003171274,0.0001137448,0.000007336163,0.0006497799,0.0003411963,0.000005058014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005822362,"about_ca_system_score_gemma":0.0007979005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001076072,"about_ca_topic_score_gemma":0.00009434201,"domain_scores_codex":[0.9974453,0.00008891192,0.00097728,0.0007228166,0.0002191524,0.0005464882],"domain_scores_gemma":[0.9985402,0.0001221238,0.0006137163,0.0004699614,0.0001085175,0.0001455477],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006072378,0.00007062724,0.00007779864,0.001022246,0.0002224015,0.0002222699,0.0001855186,0.00002713491,0.00003903617,0.0000137449,0.01666176,0.9813967],"study_design_scores_gemma":[0.0007747007,0.001096374,0.000005399273,0.004514525,0.000279258,0.00009608397,0.0006878652,0.00002173849,0.00009829395,0.00005323638,0.9919346,0.0004379132],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001863626,0.9873876,0.0002870056,0.00002735903,0.003637986,0.001114016,0.00009511354,0.00001181616,0.005575489],"genre_scores_gemma":[0.00007765774,0.9888229,0.008699517,0.0003846635,0.0004174925,0.0006119495,0.0008227268,0.00006505503,0.00009800688],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9809588,"threshold_uncertainty_score":0.9998149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03817641094660321,"score_gpt":0.3338607546956324,"score_spread":0.2956843437490292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}