{"id":"W4200384028","doi":"10.3390/jpm11121353","title":"The Need for Precision Therapies as Determined by Genetic Signature for Cystic Fibrosis","year":2021,"lang":"en","type":"editorial","venue":"Journal of Personalized Medicine","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cystic fibrosis; Signature (topology); Medicine; Field (mathematics); Bioinformatics; Computational biology; Fibrosis; Computer science; Internal medicine; Biology; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01014747,0.002558598,0.003766643,0.002080447,0.001967068,0.005211422,0.003842756,0.01443285,0.008002832],"category_scores_gemma":[0.03208392,0.000964131,0.002806055,0.0009028754,0.002185813,0.005176377,0.001565862,0.02692348,0.006621152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002268853,"about_ca_system_score_gemma":0.002919749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001094183,"about_ca_topic_score_gemma":0.003001104,"domain_scores_codex":[0.995362,0.001218158,0.0006997861,0.0004710165,0.001951959,0.0002970624],"domain_scores_gemma":[0.9656951,0.01911756,0.001165472,0.0007072449,0.01025314,0.003061481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009929106,0.0000123753,0.00003622861,0.0003636082,0.00003677043,0.0001135421,0.00001556722,0.00003163262,0.00008230615,0.0006160517,0.987592,0.01100055],"study_design_scores_gemma":[0.0001552324,0.0000883523,0.0003560686,0.0008173123,0.0001875688,0.0004218266,0.00005574244,0.0002398872,0.0002086093,0.002870558,0.9945586,0.00004017916],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"editorial","genre_gemma":"editorial","genre_scores_codex":[0.00005830986,0.01243575,0.0002091943,0.05614065,0.9300189,0.00001958672,0.00007124223,0.00006667431,0.0009797764],"genre_scores_gemma":[0.0004538564,0.01130057,0.0001585126,0.03326863,0.950661,0.00002118708,0.00004639248,0.00003148099,0.004058395],"genre_candidate":"editorial","genre_consensus":"editorial","teacher_disagreement_score":0.01443285,"threshold_uncertainty_score":0.05366558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0121557823752733,"score_gpt":0.3445082604599865,"score_spread":0.3323524780847132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}