{"id":"W4200389964","doi":"10.1002/glia.24124","title":"Context‐dependent transcriptional regulation of microglial proliferation","year":2021,"lang":"en","type":"article","venue":"Glia","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Scottish Rite Charitable Foundation of Canada","keywords":"Microglia; Biology; E2F; Transcription factor; Transcriptional regulation; Regulation of gene expression; Cell cycle; E2F1; Gene expression; Gene; Gene regulatory network; Context (archaeology); Transcription (linguistics); Cell biology; Genetics; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009125302,0.0000843541,0.0001093806,0.00005313712,0.00009528077,0.0000415041,0.00007321658,0.00004363803,0.0006116329],"category_scores_gemma":[0.0001717544,0.00008967653,0.00007342517,0.0001385838,0.00002986073,0.0001944984,0.0000141697,0.00007209273,0.00007409619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001467818,"about_ca_system_score_gemma":0.00007934129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000117174,"about_ca_topic_score_gemma":0.00001103335,"domain_scores_codex":[0.9988045,0.0001565381,0.0002886032,0.0002859992,0.0003590257,0.000105305],"domain_scores_gemma":[0.9995227,0.00003700568,0.00008767158,0.0001874605,0.0001220338,0.0000431371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002783953,0.00004789116,0.00001675706,0.000009540848,0.000001617687,0.00000846341,0.0001171082,0.0001966351,0.9047338,0.09341401,0.00013836,0.00128796],"study_design_scores_gemma":[0.0004956382,0.00003462117,0.0004636014,0.000005417663,0.000007190808,0.00004923264,0.00001186661,0.001525567,0.9924196,0.001600973,0.003309245,0.00007702917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861024,0.0000342213,0.01061073,0.000992678,0.0008309446,0.0002286317,0.00005131589,0.00007829989,0.001070759],"genre_scores_gemma":[0.9951909,0.00001530768,0.0003332685,0.0008665054,0.0001046,0.00001186352,0.00001906961,0.00001033272,0.003448197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09181304,"threshold_uncertainty_score":0.6696952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03407075680429818,"score_gpt":0.2467817141920157,"score_spread":0.2127109573877175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}