{"id":"W4200395955","doi":"10.1016/j.jmb.2021.167420","title":"Structural and Mechanistic Insight into CRISPR-Cas9 Inhibition by Anti-CRISPR Protein AcrIIC4Hpa","year":2021,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"CRISPR; Cas9; Endonuclease; DNA; Plasmid; Biology; Prophage; Genome editing; Computational biology; Cell biology; Genetics; Chemistry; Gene; Bacteriophage; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002346196,0.0003792381,0.0003459664,0.0001853024,0.0004834811,0.0006560829,0.0008219394,0.0008150238,0.004248119],"category_scores_gemma":[0.0001795208,0.0002904891,0.0003999625,0.0001381302,0.0005514619,0.0005073337,0.0003019451,0.001936532,0.001094518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008205684,"about_ca_system_score_gemma":0.0007198498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001418634,"about_ca_topic_score_gemma":0.001234603,"domain_scores_codex":[0.9998146,0.00001577895,0.0000145788,0.00005012847,0.00006463769,0.00004037297],"domain_scores_gemma":[0.9998726,0.00002377416,0.00003416251,0.00001780619,0.00001799462,0.00003363355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001222835,0.00004259116,0.0001933325,0.00008373411,0.00001118359,0.0002499832,0.00001668311,0.0009525414,0.9918056,0.00383991,0.000354976,0.002327201],"study_design_scores_gemma":[0.00002469912,0.00009816216,0.001376714,0.000009866686,0.00001506846,0.0005311057,0.00003735814,0.010555,0.9787297,0.0008787849,0.007724392,0.0000191786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.868142,0.003358486,0.09666039,0.003385615,0.0007098394,0.0001428064,0.001999018,0.002474749,0.02312703],"genre_scores_gemma":[0.9808751,0.0006934069,0.01218967,0.0003197318,0.00001766361,0.00002533993,0.0003990214,0.00006258041,0.0054175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004248119,"threshold_uncertainty_score":0.01421136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004603772281090536,"score_gpt":0.2932184528595377,"score_spread":0.2886146805784472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}