{"id":"W4200397657","doi":"10.1182/blood-2021-155156","title":"Efficacy of rFVIIIFc for First-Time Immune Tolerance Induction (ITI) Therapy: Final Results from the Global, Prospective VerITI-8 Study","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; McMaster Children's Hospital","funders":"","keywords":"Haemophilia; Interquartile range; Medicine; Haemophilia A; Factor IX; Internal medicine; Titer; Prospective cohort study; Pediatrics; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00720832,0.0006139475,0.001532602,0.0002673472,0.000236084,0.00167009,0.0007852426,0.0009466977,0.003691025],"category_scores_gemma":[0.005293075,0.0003268503,0.003018182,0.0006474467,0.0005070797,0.0009275811,0.0006192228,0.002414776,0.0007013909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000687746,"about_ca_system_score_gemma":0.0008566027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009934206,"about_ca_topic_score_gemma":0.001944944,"domain_scores_codex":[0.9977552,0.001116413,0.0002104029,0.0003556068,0.000345654,0.0002167103],"domain_scores_gemma":[0.9940841,0.002180285,0.001874955,0.0004517572,0.0006771662,0.0007318546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6004773,0.002064434,0.1258488,0.006275833,0.03436874,0.0002592836,0.0005660595,0.001415088,0.003280499,0.0009440514,0.01481703,0.209683],"study_design_scores_gemma":[0.2280367,0.1315034,0.5212741,0.00484111,0.07413371,0.001477636,0.0007424964,0.001474928,0.003036405,0.001561338,0.03168376,0.0002343711],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8467714,0.1313225,0.0009581852,0.002014748,0.0005216675,0.0007218673,0.01140489,0.00007980408,0.006204829],"genre_scores_gemma":[0.9756894,0.01175299,0.0008332208,0.00120026,0.0002625698,0.0003557879,0.00852976,0.00003932588,0.001336795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00720832,"threshold_uncertainty_score":0.0381217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04379315182001176,"score_gpt":0.3188160811657789,"score_spread":0.2750229293457672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}