{"id":"W4200401092","doi":"10.3389/fcvm.2021.795868","title":"New Strategies to Promote Macrophage Cholesterol Efflux","year":2021,"lang":"en","type":"article","venue":"Frontiers in Cardiovascular Medicine","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"ABCA1; Efflux; Cholesterol; Macrophage; ABCG1; THP1 cell line; Reverse cholesterol transport; Pharmacology; Cell biology; Lipid metabolism; Biology; Chemistry; Biochemistry; Transporter; Cell culture; In vitro; Lipoprotein; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008037445,0.0003681777,0.001580461,0.000372236,0.00005171277,0.0000401512,0.0002026959,0.0001979192,0.0001814867],"category_scores_gemma":[0.0002903535,0.0003092745,0.0005584871,0.001008847,0.00009347375,0.0001568288,0.0001073292,0.0005198564,0.00005723804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000150782,"about_ca_system_score_gemma":0.0004258203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002032592,"about_ca_topic_score_gemma":0.00001952518,"domain_scores_codex":[0.9969516,0.0001542099,0.0005380461,0.0007799751,0.0009928448,0.0005833117],"domain_scores_gemma":[0.9977636,0.00001614468,0.00004881821,0.001316915,0.0001690151,0.0006854723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003047875,0.0002272292,0.04030779,0.0007269541,0.003518666,0.002748445,0.005895523,0.0006247881,0.01300464,0.0001709169,0.1350368,0.7974334],"study_design_scores_gemma":[0.009888875,0.0002470262,0.2690083,0.0008633183,0.001019028,0.0007236412,0.001887744,0.00005644991,0.003670061,0.0003172487,0.711958,0.0003602906],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3189333,0.222297,0.4006293,0.01514635,0.01558006,0.003009204,0.00001815551,0.0004207856,0.02396581],"genre_scores_gemma":[0.8362878,0.001968647,0.1190129,0.009794483,0.01294702,0.0001717952,0.0002194105,0.000303402,0.01929457],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7970731,"threshold_uncertainty_score":0.9999359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01028320964191634,"score_gpt":0.2515899006401494,"score_spread":0.241306690998233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}