{"id":"W4200401093","doi":"10.4049/jimmunol.2100452","title":"Prosurvival IL-7–Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1–TCF1–Id3 and Metabolic AMPKα1–ULK1–ATG7 Pathways","year":2021,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"AMPK; mTORC1; Cell biology; T cell; FOXO1; Biology; Chemistry; Signal transduction; Kinase; Immune system; PI3K/AKT/mTOR pathway; Protein kinase A; Immunology; Protein kinase B","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001024759,0.0003391614,0.0002124891,0.0002141106,0.0001668643,0.0002950215,0.0001696495,0.0002258783,0.001583986],"category_scores_gemma":[0.0000562596,0.0001320979,0.0002698069,0.0001070298,0.0003845079,0.0002256507,0.0001895406,0.0006896717,0.0004145577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002427713,"about_ca_system_score_gemma":0.0001560728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002317492,"about_ca_topic_score_gemma":0.0005034323,"domain_scores_codex":[0.999827,0.00001947823,0.00001589599,0.0000451845,0.00003007607,0.00006245358],"domain_scores_gemma":[0.9999034,0.000006692389,0.00003386281,0.000009400619,0.0000079232,0.00003870343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002179918,0.00002335077,0.0002079723,0.00002558688,0.000002763546,0.00002083033,0.00001034444,0.00003250502,0.9989059,0.00008033432,0.00002981159,0.0004425715],"study_design_scores_gemma":[0.00004172954,0.0003145947,0.007851981,0.00001147482,0.00001894251,0.0001077543,0.00007052664,0.0009490302,0.9890624,0.00009656955,0.001470718,0.000004277365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967578,0.0006468643,0.0009796697,0.00009297893,0.00002960549,0.00001197828,0.0003678728,0.00007223412,0.001041035],"genre_scores_gemma":[0.9970785,0.0003190505,0.0007166487,0.00004614607,0.00001241987,0.00003251349,0.0003097083,0.0000187604,0.00146632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001583986,"threshold_uncertainty_score":0.005298972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01062571148297831,"score_gpt":0.2075348737022792,"score_spread":0.1969091622193009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}