{"id":"W4200401431","doi":"10.1128/spectrum.01318-21","title":"<i>In Vitro</i> and <i>In Vivo</i> Studies on the Antibacterial Activity and Safety of a New Antimicrobial Peptide Dermaseptin-AC","year":2021,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Beijing University of Chinese Medicine; China Scholarship Council; Queen's University","keywords":"In vivo; Antimicrobial; Microbiology; Hemolysis; Antimicrobial peptides; In vitro; Chemistry; Pharmacology; Staphylococcus aureus; Biology; Bacteria; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003343688,0.0003579172,0.0008478476,0.0001356372,0.0002142383,0.00001687924,0.0001663407,0.0003409496,0.0001810983],"category_scores_gemma":[0.00009401768,0.0002793097,0.000106149,0.0002035222,0.00107033,0.0001226425,0.0003396834,0.0005919077,0.00001866079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000573239,"about_ca_system_score_gemma":0.0001485039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000366865,"about_ca_topic_score_gemma":0.0008604367,"domain_scores_codex":[0.9977421,0.0005347997,0.0005169761,0.0005966137,0.00001773289,0.0005918071],"domain_scores_gemma":[0.9988413,0.0005715163,0.000234446,0.0002956783,0.0000318922,0.0000251185],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001706637,0.00013817,0.001422292,0.00004793701,0.0001658571,0.00004955293,0.0008995431,0.000003532852,0.9883561,0.0003792814,0.006728229,0.000102922],"study_design_scores_gemma":[0.002339246,0.0001072915,0.002203475,0.0001427278,0.00003288125,0.0004415351,0.0007474865,8.510688e-7,0.9858516,0.0001347674,0.007723573,0.0002745586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916896,0.001269152,0.000005893737,0.005238269,0.0007845939,0.0003125881,0.0002270108,0.00002076858,0.0004521309],"genre_scores_gemma":[0.9942366,0.001216944,0.00008928218,0.001565305,0.00008636353,0.000004787983,0.00002941294,0.00002361139,0.002747633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003672963,"threshold_uncertainty_score":0.9999659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.012656046314064,"score_gpt":0.2329461996689843,"score_spread":0.2202901533549203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}