{"id":"W4200401431","doi":"10.1128/spectrum.01318-21","title":"<i>In Vitro</i> and <i>In Vivo</i> Studies on the Antibacterial Activity and Safety of a New Antimicrobial Peptide Dermaseptin-AC","year":2021,"lang":"en","type":"article","venue":"Microbiology Spectrum","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Beijing University of Chinese Medicine; China Scholarship Council; Queen's University","keywords":"In vivo; Antimicrobial; Microbiology; Hemolysis; Antimicrobial peptides; In vitro; Chemistry; Pharmacology; Staphylococcus aureus; Biology; Bacteria; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007120367,0.0006012801,0.0004371737,0.0002933463,0.0002114722,0.0002787316,0.0002401091,0.0003758938,0.002182906],"category_scores_gemma":[0.0004146947,0.0001414147,0.0006888394,0.000186898,0.0003469573,0.0003386986,0.0001378965,0.0007997341,0.0005008894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002398014,"about_ca_system_score_gemma":0.0002418036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007680876,"about_ca_topic_score_gemma":0.0005183872,"domain_scores_codex":[0.9995844,0.0001733167,0.00002962624,0.0000743987,0.0000570259,0.00008119543],"domain_scores_gemma":[0.999435,0.0001757395,0.0001548757,0.00004786422,0.0001115048,0.00007494463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006481958,0.0002895808,0.0001531578,0.000175856,0.00001304233,0.00005387224,0.00001702534,0.0001938218,0.9952852,0.00006123229,0.00009477704,0.003014273],"study_design_scores_gemma":[0.00007453623,0.01170415,0.001770774,0.00001339308,0.00006161799,0.0003313707,0.00002073224,0.0005487078,0.9834263,0.00005140707,0.001986012,0.00001090179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9606121,0.01383082,0.015735,0.0004220167,0.0003251382,0.0003263121,0.00111909,0.0001132324,0.007516371],"genre_scores_gemma":[0.9806472,0.005450516,0.007629178,0.0002896724,0.0001610679,0.0001255415,0.001349302,0.0000347342,0.004312866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002182906,"threshold_uncertainty_score":0.007302523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.012656046314064,"score_gpt":0.2329461996689843,"score_spread":0.2202901533549203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}