{"id":"W4200407778","doi":"10.1182/blood-2021-151493","title":"Updated Results of a Phase 1/2 Study of Lower Dose CPX-351 for Patients with Int-2 or High Risk IPSS Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia after Failure to Hypomethylating Agents","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Cytarabine; Chronic myelomonocytic leukemia; Daunorubicin; Internal medicine; Azacitidine; Myelodysplastic syndromes; Hypomethylating agent; Gastroenterology; Leukemia; Oncology; Surgery; Bone marrow","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004610751,0.001047119,0.00166429,0.0003663061,0.0003451226,0.001052869,0.0009304428,0.001093036,0.002661066],"category_scores_gemma":[0.002277913,0.0004526644,0.001578535,0.0004721633,0.000507956,0.0006778512,0.0003285987,0.002543535,0.0005259003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001026124,"about_ca_system_score_gemma":0.001591989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001443471,"about_ca_topic_score_gemma":0.002960023,"domain_scores_codex":[0.9985951,0.000798733,0.0001078757,0.0001524809,0.0001820561,0.0001638382],"domain_scores_gemma":[0.9976314,0.0005798156,0.0006006602,0.0002252433,0.0003314454,0.0006313666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5312694,0.04597994,0.04319571,0.001691629,0.007103334,0.0005133688,0.0006050058,0.007993,0.1300588,0.0004471637,0.02072996,0.2104128],"study_design_scores_gemma":[0.353383,0.4863531,0.1092588,0.000118012,0.006675601,0.0009418461,0.0001249639,0.002277618,0.01871385,0.0004051429,0.0216461,0.0001019714],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830564,0.003452979,0.001023968,0.001244974,0.0001244204,0.002036331,0.006627782,0.0001055621,0.002327545],"genre_scores_gemma":[0.9670596,0.002138927,0.00437555,0.00282308,0.0002216466,0.003001106,0.01798552,0.00007463169,0.002319886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004610751,"threshold_uncertainty_score":0.02438426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01671533418635717,"score_gpt":0.2934423340101172,"score_spread":0.27672699982376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}