{"id":"W4200416029","doi":"10.1099/acmi.cc2021.po0006","title":"Exploiting diverse chemical collections to uncover novel antifungals","year":2021,"lang":"en","type":"article","venue":"Access Microbiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Candida auris; Fluconazole; Cryptococcus neoformans; Efflux; Microbiology; Biology; Candida albicans; Chemical library; Candida glabrata; Antifungal; Biochemistry; Small molecule","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006234769,0.001102004,0.001280766,0.003307688,0.0006095823,0.001871585,0.0009055191,0.0006542242,0.005656856],"category_scores_gemma":[0.0006198758,0.0004828827,0.0008647561,0.001845601,0.0003753633,0.0014356,0.001148616,0.001064576,0.001911321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008908454,"about_ca_system_score_gemma":0.001164485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009840984,"about_ca_topic_score_gemma":0.003622823,"domain_scores_codex":[0.9995485,0.00003775173,0.00002876632,0.00008898937,0.000195747,0.0001002676],"domain_scores_gemma":[0.9997274,0.00005242761,0.00004111058,0.00004233846,0.00007235873,0.00006428063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008251347,0.0009471441,0.004053995,0.001156538,0.0001961426,0.001298449,0.0001666938,0.005312101,0.7755665,0.00380843,0.004358951,0.2023099],"study_design_scores_gemma":[0.000786158,0.006924727,0.01171627,0.0003045826,0.0007765933,0.003175298,0.0005025608,0.01062262,0.7947779,0.004438069,0.1657832,0.0001919625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.862078,0.03488548,0.03562469,0.002872372,0.0002879071,0.002306888,0.0138393,0.003707743,0.04439769],"genre_scores_gemma":[0.8634736,0.04015858,0.05218149,0.002641135,0.000248754,0.0009483582,0.02053697,0.0003627252,0.01944822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005656856,"threshold_uncertainty_score":0.01892412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05422900453112521,"score_gpt":0.3427113968012757,"score_spread":0.2884823922701505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}