{"id":"W4200418065","doi":"10.2174/1570193x19666211221150119","title":"Discovery and Development of Antibacterial Agents: Fortuitous and Designed","year":2021,"lang":"en","type":"article","venue":"Mini-Reviews in Medicinal Chemistry","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cape Breton University","funders":"","keywords":"Clinical trial; Antibiotics; Drug development; Drug discovery; Drug resistance; Antibiotic resistance; Broad spectrum","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002628803,0.0001307612,0.0002723882,0.00001041297,0.00002598542,0.00001085645,0.00006941772,0.00009353609,0.00002988194],"category_scores_gemma":[0.00005878146,0.0001175689,0.00002925826,0.00004419763,0.00006677414,0.000003465456,0.00009355661,0.00005853426,2.814424e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001226422,"about_ca_system_score_gemma":0.0001480678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002493792,"about_ca_topic_score_gemma":0.00001432736,"domain_scores_codex":[0.9991341,0.00002598903,0.0003327451,0.0002714546,0.00009190104,0.0001438685],"domain_scores_gemma":[0.9996423,0.000008372464,0.00009486614,0.0001743769,0.00002249656,0.00005759322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004509452,0.00003602525,0.0003062199,0.0002951827,0.0000207836,0.000009591869,0.0001267579,5.111867e-8,0.9336718,0.000002780304,0.00008514394,0.06540059],"study_design_scores_gemma":[0.0006963024,0.00004666489,0.0005835395,0.0002595347,0.00002059207,0.00004748648,0.0001695185,0.000001746478,0.9049351,0.00001714518,0.09309591,0.0001265193],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702018,0.02817933,0.001128772,0.00004585034,0.0001041816,0.0001080006,0.000007807369,0.000001656415,0.0002226126],"genre_scores_gemma":[0.9725734,0.02168014,0.004547455,0.0003228573,0.0002297609,0.00002906768,0.0001085563,0.00001691281,0.0004918738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09301076,"threshold_uncertainty_score":0.479432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02748821031224511,"score_gpt":0.2923584075383907,"score_spread":0.2648701972261455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}