{"id":"W4200420013","doi":"10.3390/molecules26247669","title":"Effects of Specific Inhibitors for CaMK1D on a Primary Neuron Model for Alzheimer’s Disease","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates Bio Solutions; Wellcome Trust; Wellcome","keywords":"Hyperphosphorylation; Disease; Programmed cell death; Dementia; Amyloid beta; Cyclin-dependent kinase 5; Kinase; Tau protein; Alzheimer's disease; Neurotoxicity; Amyloid (mycology); Neuroscience; GSK-3; Toxicity; Pharmacology; Calmodulin; Biology; Protein kinase A; Medicine; Cell biology; Enzyme; Internal medicine; Biochemistry; Pathology; Apoptosis; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002021693,0.0008073986,0.0009935971,0.00033141,0.0002704952,0.0002795404,0.0005861598,0.000565408,0.001625265],"category_scores_gemma":[0.0001180199,0.0001835083,0.000537659,0.0002357995,0.0002221114,0.0002700295,0.0001373734,0.001299609,0.0003466984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004399694,"about_ca_system_score_gemma":0.0004552148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001445335,"about_ca_topic_score_gemma":0.002856209,"domain_scores_codex":[0.9998263,0.00001946628,0.00002299527,0.00004161373,0.00003562223,0.0000540926],"domain_scores_gemma":[0.9999038,0.00001672322,0.00002046985,0.000009698327,0.00001765904,0.00003156928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001264059,0.0008026562,0.000118429,0.0002957918,0.00004038573,0.000125595,0.00002769486,0.0002202007,0.993535,0.0001243865,0.0004211568,0.003024492],"study_design_scores_gemma":[0.0001720069,0.003013152,0.001363661,0.00001580798,0.00007224347,0.0001759228,0.00002599751,0.001039631,0.9919687,0.00003764886,0.002105333,0.000009904744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849874,0.008264042,0.001779675,0.0003471327,0.0004720856,0.0001338192,0.001115702,0.0001972417,0.002702983],"genre_scores_gemma":[0.9815594,0.008421571,0.003777048,0.0001668047,0.00005146827,0.0002735348,0.001329322,0.00003254382,0.004388249],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001625265,"threshold_uncertainty_score":0.005437076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03314178376288174,"score_gpt":0.3023865247060567,"score_spread":0.269244740943175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}