{"id":"W4200420013","doi":"10.3390/molecules26247669","title":"Effects of Specific Inhibitors for CaMK1D on a Primary Neuron Model for Alzheimer’s Disease","year":2021,"lang":"en","type":"article","venue":"Molecules","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates Bio Solutions; Wellcome Trust; Wellcome","keywords":"Hyperphosphorylation; Disease; Programmed cell death; Dementia; Amyloid beta; Cyclin-dependent kinase 5; Kinase; Tau protein; Alzheimer's disease; Neurotoxicity; Amyloid (mycology); Neuroscience; GSK-3; Toxicity; Pharmacology; Calmodulin; Biology; Protein kinase A; Medicine; Cell biology; Enzyme; Internal medicine; Biochemistry; Pathology; Apoptosis; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004098263,0.000174242,0.0002827202,0.00007943499,0.00006548124,0.00001298355,0.00005704075,0.00004474706,0.0000060434],"category_scores_gemma":[0.0001171381,0.0001501101,0.0002892812,0.00009369021,0.00005771452,0.0000356754,0.00003688912,0.00006289059,0.000008267428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004255636,"about_ca_system_score_gemma":0.0003712031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002163011,"about_ca_topic_score_gemma":6.539927e-7,"domain_scores_codex":[0.9988104,0.00003359746,0.0001793458,0.0003600532,0.000305049,0.0003115253],"domain_scores_gemma":[0.9988896,0.0002138827,0.00005085384,0.0002964762,0.0001653761,0.0003837846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.103473,0.05571264,0.01540968,0.0258397,0.06128529,0.0132974,0.001314428,0.004046285,0.3351119,0.0244817,0.1937372,0.1662908],"study_design_scores_gemma":[0.03274984,0.004651573,0.06432068,0.001505207,0.009018129,0.00002047449,0.00006272978,0.04982428,0.8265787,0.006256211,0.004022195,0.0009899761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9131704,0.06932348,0.008089163,0.001826857,0.0002384177,0.005727441,0.0007389731,0.0001072886,0.0007779544],"genre_scores_gemma":[0.9956435,0.0002518164,0.002387246,0.0004301021,0.0001152269,0.0005589161,0.0004413955,0.00005800796,0.0001138012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4914668,"threshold_uncertainty_score":0.6121314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03314178376288174,"score_gpt":0.3023865247060567,"score_spread":0.269244740943175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}