{"id":"W4200424134","doi":"10.3389/fmicb.2021.779176","title":"The Importance of Vacuolar Ion Homeostasis and Trafficking in Hyphal Development and Virulence in Candida albicans","year":2021,"lang":"en","type":"review","venue":"Frontiers in Microbiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Concordia University; National Natural Science Foundation of China","keywords":"Vacuole; Candida albicans; Biology; Virulence; Cell biology; ATPase; Corpus albicans; Homeostasis; Cytosol; Microbiology; Biochemistry; Cytoplasm; Enzyme; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000270555,0.0004891057,0.0007529681,0.001488857,0.0002035135,0.0007859265,0.0004655131,0.0007402502,0.002390978],"category_scores_gemma":[0.0004868537,0.0001661674,0.0004028908,0.001483434,0.0002450618,0.0007627985,0.0004495219,0.0009606032,0.0008930137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003860308,"about_ca_system_score_gemma":0.001087419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001201712,"about_ca_topic_score_gemma":0.001720659,"domain_scores_codex":[0.9998851,0.0000150511,0.00002015289,0.00001766313,0.00004928569,0.00001286472],"domain_scores_gemma":[0.9998324,0.00007016708,0.00002809151,0.000004094475,0.00004922123,0.00001591358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008460975,0.00003698752,0.0002407096,0.02432517,0.00009033793,0.0002814932,0.00007165638,0.0002555878,0.003327987,0.00254507,0.02233006,0.9464104],"study_design_scores_gemma":[0.00001500328,0.0001178181,0.00211519,0.00603479,0.0002072336,0.002154394,0.00008850176,0.0001106193,0.001006133,0.001712403,0.9864146,0.00002329549],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001685506,0.9988551,0.00006428894,0.0001796775,0.0001139048,0.000001958565,0.00001726723,0.000005943157,0.0005932927],"genre_scores_gemma":[0.0007839035,0.998642,0.00008390142,0.00009142866,0.0000780141,0.000002035146,0.00002403091,7.664851e-7,0.0002939651],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002390978,"threshold_uncertainty_score":0.007998645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02145510017889428,"score_gpt":0.2958000340474127,"score_spread":0.2743449338685184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}