{"id":"W4200426793","doi":"10.1016/j.jcyt.2021.09.003","title":"Curative therapy for hemoglobinopathies: an International Society for Cell & Gene Therapy Stem Cell Engineering Committee review comparing outcomes, accessibility and cost of ex vivo stem cell gene therapy versus allogeneic hematopoietic stem cell transplantation","year":2021,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Medicine; Genetic enhancement; Thalassemia; Hematopoietic stem cell transplantation; Stem cell; Disease; Hematopoietic stem cell; Transplantation; Cell therapy; Stem-cell therapy; Haematopoiesis; Intensive care medicine; Immunology; Oncology; Internal medicine; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007628683,0.0007283059,0.001389921,0.0001104746,0.0002401832,0.0000936381,0.0004320628,0.0003854575,0.00006467669],"category_scores_gemma":[0.000003114818,0.0006093257,0.000797764,0.0003392826,0.0001325851,0.0003098387,0.00003213823,0.0003754478,0.000002818677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002102035,"about_ca_system_score_gemma":0.0003205849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001916117,"about_ca_topic_score_gemma":0.000009343551,"domain_scores_codex":[0.9965034,0.0001725474,0.001212147,0.0009793596,0.0005201384,0.0006123668],"domain_scores_gemma":[0.9972607,0.0004930599,0.0005996575,0.0008346948,0.0005447495,0.0002670992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007138216,0.004256238,0.01603897,0.007879443,0.001345893,0.000024493,0.01715264,0.0008074056,0.9099879,0.00004264804,0.001407459,0.03391865],"study_design_scores_gemma":[0.04243087,0.001637444,0.002040608,0.0006491933,0.0002579843,0.00003548082,0.002499047,0.001696647,0.9265926,0.00002225278,0.02115993,0.0009779775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8914068,0.09184203,0.01068093,0.0004260486,0.0005902209,0.004357249,0.0003419234,0.0001202154,0.000234632],"genre_scores_gemma":[0.6645285,0.3265284,0.005377364,0.001664227,0.0001251479,0.0004920904,0.0004941453,0.000177979,0.000612193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2346863,"threshold_uncertainty_score":0.9996358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0467885788004244,"score_gpt":0.3060007548602737,"score_spread":0.2592121760598493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}