{"id":"W4200426793","doi":"10.1016/j.jcyt.2021.09.003","title":"Curative therapy for hemoglobinopathies: an International Society for Cell & Gene Therapy Stem Cell Engineering Committee review comparing outcomes, accessibility and cost of ex vivo stem cell gene therapy versus allogeneic hematopoietic stem cell transplantation","year":2021,"lang":"en","type":"article","venue":"Cytotherapy","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Medicine; Genetic enhancement; Thalassemia; Hematopoietic stem cell transplantation; Stem cell; Disease; Hematopoietic stem cell; Transplantation; Cell therapy; Stem-cell therapy; Haematopoiesis; Intensive care medicine; Immunology; Oncology; Internal medicine; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01164541,0.0004139981,0.001866024,0.001871825,0.0002884246,0.001663972,0.000870552,0.001067449,0.001826244],"category_scores_gemma":[0.01153099,0.000211849,0.002169624,0.002487438,0.000591831,0.0009275167,0.0006263171,0.001430469,0.0003414303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002315083,"about_ca_system_score_gemma":0.006520763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002725663,"about_ca_topic_score_gemma":0.006507478,"domain_scores_codex":[0.9971657,0.001278277,0.0005984649,0.000202788,0.0006488745,0.0001057532],"domain_scores_gemma":[0.9879273,0.008277719,0.001651702,0.0001898444,0.001765544,0.0001879733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.001136986,0.00009699471,0.00131833,0.03778291,0.001332332,0.00007129904,0.00007712706,0.0003335828,0.001331798,0.003473692,0.03557779,0.9174672],"study_design_scores_gemma":[0.0009207339,0.002630361,0.01495308,0.1491684,0.01103066,0.0009035437,0.0004358575,0.000217643,0.002860201,0.002934722,0.8138731,0.00007191457],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006799558,0.99505,0.000169777,0.002453428,0.0003936799,0.00004494645,0.00009332735,0.000003482627,0.001111359],"genre_scores_gemma":[0.006784109,0.9869768,0.0008063532,0.004108537,0.0005102602,0.0001406035,0.0002198693,0.00001114309,0.0004423964],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01164541,"threshold_uncertainty_score":0.06158751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0467885788004244,"score_gpt":0.3060007548602737,"score_spread":0.2592121760598493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}