{"id":"W4200431462","doi":"10.1002/bies.202100152","title":"Rho GTPases: Non‐canonical regulation by cysteine oxidation","year":2021,"lang":"en","type":"review","venue":"BioEssays","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Ryerson University","keywords":"GTPase; Cell biology; Phosphorylation; Cysteine; CDC42; Biochemistry; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003193214,0.0004420295,0.0008451043,0.00009298095,0.0001179297,0.00007854524,0.0002471269,0.0007763956,0.0001275365],"category_scores_gemma":[0.0001256863,0.0004062532,0.0004908198,0.0002677828,0.00007319663,0.00000656255,0.0001628889,0.0001814218,0.00006061715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006788409,"about_ca_system_score_gemma":0.0004312291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001238314,"about_ca_topic_score_gemma":0.000006419458,"domain_scores_codex":[0.9977898,0.0002444958,0.0006439893,0.0007522584,0.0002677179,0.0003017098],"domain_scores_gemma":[0.9985986,0.00002260324,0.0004035773,0.0006914348,0.0001425718,0.0001411722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001823499,0.0001660131,0.000003654968,0.004497976,0.0002981885,0.00001838732,0.000007218988,0.000008180818,0.05462342,0.0005438656,0.03815507,0.9016598],"study_design_scores_gemma":[0.0002701659,0.00009231202,9.932085e-7,0.002458253,0.0002303415,0.00003995964,0.000004381991,0.00001947353,0.008529689,0.00001068805,0.987883,0.0004607369],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007536051,0.9931798,0.004855779,0.00003697415,0.0002131304,0.0006283703,0.0001342222,0.00003064934,0.0008457222],"genre_scores_gemma":[0.0006764563,0.9804112,0.0006242068,0.00007232619,0.0006983849,0.0001549006,0.01464628,0.00008174487,0.002634519],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.949728,"threshold_uncertainty_score":0.9998389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02309283680546113,"score_gpt":0.3091869158354464,"score_spread":0.2860940790299853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}