{"id":"W4200433804","doi":"10.21203/rs.3.rs-1194231/v1","title":"The Molecular Determinants of Antigenic Drift in a Novel Avian Influenza A (H9N2) Variant Virus","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"State Key Laboratory of Veterinary Biotechnology; National Natural Science Foundation of China; University of Ottawa; University of Wisconsin-Madison","keywords":"Antigenicity; Antigenic drift; Hemagglutination assay; Virology; Biology; Antigenic variation; Antigen; Virus; Titer; Epitope; Amino acid; Antigenic shift; Influenza A virus; Immune system; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001140407,0.0003061068,0.0001311566,0.0001566503,0.0001357721,0.000129016,0.0001663397,0.0002052866,0.0003294305],"category_scores_gemma":[0.0001234818,0.00008018643,0.0002701812,0.0001103624,0.0001504817,0.0001095453,0.0001195118,0.0002639075,0.0001057508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002356242,"about_ca_system_score_gemma":0.0001289285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001393502,"about_ca_topic_score_gemma":0.001480729,"domain_scores_codex":[0.9999278,0.00001165314,0.00000739751,0.00001513675,0.00002320341,0.00001477732],"domain_scores_gemma":[0.9999216,0.00001184097,0.00002545871,0.000006854526,0.00001231505,0.00002193431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009949742,0.00002633625,0.002990516,0.00001596249,0.0000132705,0.0002032957,0.00002003588,0.0001312845,0.9954803,0.00003617272,0.00001724885,0.0009660954],"study_design_scores_gemma":[0.00006520223,0.002454181,0.1907986,0.0000201911,0.0001705624,0.005768073,0.0002491634,0.009890744,0.7874227,0.00019178,0.002935344,0.00003342074],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994295,0.000087093,0.0002774147,0.000007705609,0.000004665815,0.000005709827,0.0000380344,0.000003278825,0.0001465309],"genre_scores_gemma":[0.9989449,0.00005461168,0.000561168,0.00002440355,0.000004099631,0.000005752933,0.0001922722,0.000003026083,0.0002098579],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001393502,"threshold_uncertainty_score":0.002770782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1457302802177821,"score_gpt":0.4744946289550965,"score_spread":0.3287643487373144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}