{"id":"W4200438336","doi":"10.1515/cclm-2021-1287","title":"Commercial immunoassays for detection of anti-SARS-CoV-2 spike and RBD antibodies: urgent call for validation against new and highly mutated variants","year":2021,"lang":"en","type":"article","venue":"Clinical Chemistry and Laboratory Medicine (CCLM)","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Spike Protein; Immunoassay; Antibody; Virology; Computational biology; Coronavirus disease 2019 (COVID-19); Epitope; Virus; Biology; Disease; Genetics; Medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001269632,0.000257839,0.0008588995,0.00004757421,0.0001506394,0.00002469568,0.00008434115,0.0003841502,0.000005737566],"category_scores_gemma":[0.00492374,0.0002234282,0.00009659304,0.0002962502,0.0005246971,0.00009273609,0.00007864378,0.0003690232,6.103668e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003445912,"about_ca_system_score_gemma":0.0006320035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004227455,"about_ca_topic_score_gemma":0.00001059424,"domain_scores_codex":[0.997829,0.00009030795,0.0008972188,0.0005953347,0.0002715952,0.0003166037],"domain_scores_gemma":[0.9974961,0.000989167,0.0002520132,0.0003298353,0.0007534042,0.0001795281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001063405,0.0002037679,0.01147892,0.001393866,0.0001797596,0.000037955,0.0001499087,9.680166e-8,0.9750808,0.00001218954,0.001790834,0.008608458],"study_design_scores_gemma":[0.009354603,0.0006495868,0.008942536,0.0004431604,0.0003452944,0.00002944594,0.0002747834,0.0004551646,0.9350873,0.0001047718,0.04409552,0.0002178727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937583,0.002500073,0.001217036,0.001363631,0.0002841328,0.0005620935,0.00010539,0.0000401118,0.0001692739],"genre_scores_gemma":[0.9891491,0.0005977181,0.0004278932,0.008702909,0.0008834512,0.00003406351,0.0001196494,0.0000375541,0.0000476507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04230468,"threshold_uncertainty_score":0.9111138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.079930758594663,"score_gpt":0.4050324487402569,"score_spread":0.3251016901455939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}